Evidence map›Paper›PMID 37189658›Full record

ArticleBiomedicines2023

Clinicopathological Significance of Cancer Stem Cell Markers (OCT-3/4 and SOX-2) in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma.

Divyambika Catakapatri Venugopal, Cynthia Leslie Caleb, Nandhini Priyadarshini Kirupakaran, Vidyarani Shyamsundar, Soundharya Ravindran, Madhavan Yasasve, Arvind Krishnamurthy, Thamizhchelvan Harikrishnan, Sathasivasubramanian Sankarapandian, Vijayalakshmi Ramshankar

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Journal of international medical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Divyambika Catakapatri VenugopalDepartment of Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.ORCID 0000-0002-1344-8678
Cynthia Leslie CalebDepartment of Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.
Nandhini Priyadarshini KirupakaranDepartment of Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.
Vidyarani ShyamsundarCentre for Oral Cancer Prevention and Research, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India.
Soundharya RavindranDepartment of Preventive Oncology (Research), Cancer Institute (WIA), Adyar, Chennai 600020, India.
Madhavan YasasveDepartment of Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.ORCID 0000-0001-7029-3679
Arvind KrishnamurthyDepartment of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai 600020, India.
Thamizhchelvan HarikrishnanDepartment of Oral Pathology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.
Sathasivasubramanian SankarapandianDepartment of Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai 600116, India.
Vijayalakshmi RamshankarDepartment of Preventive Oncology (Research), Cancer Institute (WIA), Adyar, Chennai 600020, India.
Sri Ramachandra Institute of Higher Education and Research · INCancer Institute (WIA) · INSree Balaji Dental College and Hospital · IN

Funding

Sri Ramachandra Institute of Higher Education and Research Chancellor Summer Fellowship
6 · The paper itself

Abstract

Oral submucous fibrosis (OSMF) is highly prevalent in South East Asia with higher rates of malignant transformation in Indian subcontinent. Numerous biomarkers are now being studied to predict disease prognosis and detect malignant alterations at an early stage. Patients with clinically and biopsy-proven oral submucous fibrosis and oral squamous cell carcinoma were included in the study as the experimental group, while patients without a tobacco or betel nut habit who had their third molars surgically removed were included as the healthy control group. For the immunohistochemistry (IHC) investigation, 5-μm slices from formalin-fixed, paraffin-embedded tissue blocks (FFPE) were obtained. Fresh tissues (

Indexed as

immunohistochemistrymalignant transformationoctamer-binding transcription factor 3/4 (OCT-3/4)oral submucous fibrosisreal-time PCRsex-determining region Y-box 2 (SOX-2)

Identifiers

PMID37189658
PMCPMC10136201
OpenAlexW4361221814

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.