Evidence map›Paper›PMID 37190274›Full record

ArticleCancers2023

Association of Suppressive Myeloid Cell Enrichment with Aggressive Oropharynx Squamous Cell Carcinoma.

Changlin Yang, Rekha Garg, Kristanna Fredenburg, Frances Weidert, Hector Mendez-Gomez, Robert Amdur, Ji-Hyun Lee, Jamie Ku, Jesse Kresak, Stephanie Staras and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Changlin YangDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-5687-600X
Rekha GargDepartment of Pediatrics, University of Florida, Gainesville, FL 32603, USA.
Kristanna FredenburgDepartment of Pathology, University of Florida, Gainesville, FL 32610, USA.
Frances WeidertDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Hector Mendez-GomezDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Robert AmdurDepartment of Radiation Oncology, University of Florida, Gainesville, FL 32608, USA.
Ji-Hyun LeeDepartment of Biostatistics, University of Florida, Gainesville, FL 32603, USA.
Jamie KuHead and Neck Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Jesse KresakDepartment of Pathology, University of Florida, Gainesville, FL 32610, USA.
Stephanie StarasDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-0726-1524
Andrew G SikoraDepartment of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
Lily WangTranslational Hematology and Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
Daniel McGrailLerner Research Institute, Cleveland Clinic, Center of Immunotherapy and Precision Immuno-Oncology, Cleveland, OH 44106, USA.
Duane MitchellDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Elias SayourDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Natalie SilverHead and Neck Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
University of Florida · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USThe University of Texas MD Anderson Cancer Center · USUniversity of Florida Health · US

Funding

Targeting the immunosuppressive tumor microenvironment to enhance efficacy of radiotherapy and immuno-radiotherapy for oral cancerU01DE028233 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANNAPRAGADA, ANANTH V, SIKORA, ANDREW · 2018 to 2022
$3.9M
VISTA, a novel checkpoint that suppresses anti-tumor T cell responsesR01CA164225 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI WANG, LI LILY · 2012 to 2023
$3.3M
Remodeling host immunity in oral cancer with personalized RNA nanoparticle vaccinesK08DE029503 · NIDCR · UNIVERSITY OF FLORIDA · PI SILVER, NATALIE LEA · 2020 to 2024
$777k
NCI NIH HHS R01 CA164225NIDCR NIH HHS K08 DE029503NIDCR NIH HHS U01 DE028233
6 · The paper itself

Abstract

backgroundWhile immune-cell infiltrated tumors, such as human papillomavirus positive (HPV+) ororpharyngeal squamous cell carcinomas (OPSCC) have been associated with an improved clinical prognosis, there is evidence to suggest that OPSCCs are also subjected to increased immunoregulatory influence. The objective of this study was to assess whether patients with clinically aggressive OPSCC have a distinct immunosuppressive immune signature in the primary tumor.

methodsThis retrospective case-control study analyzed 37 pre-treatment tissue samples from HPV+ and HPV-negative OPSCC patients treated at a single institution. The cases were patients with known disease recurrence and the controls were patients without disease recurrence. An mRNA-expression immune-pathway profiling was performed, and correlated to clinical outcomes. The TCGA head and neck cancer database was utilized to make comparisons with the institutional cohort.

resultsIn our cohort, HPV-negative and HPV+ patients with known disease recurrence both had significantly increased suppressive monoctyte/macrophage and granulocyte cell-expression-profile enrichment. Similar findings were found in the TCGA cohort when comparing HPV-negative to positive patients.

conclusionsour study demonstrates that patients with recurrent HPV+ OPSCC had suppressive monocyte/macrophage and granulocyte immune-cell enrichment, similar to those seen in the more aggressive HPV-negative OPSCC.

Indexed as

head and neck cancerhuman papillomavirusmyeloid celloropharynx cancerTCGA

Identifiers

PMID37190274
PMCPMC10136648
OpenAlexW4366283414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.