Evidence map›Paper›PMID 37191721›Full record

ArticleLangenbeck's archives of surgery2023

Simultaneous pancreas-kidney transplantation: which graft warns the most?

Tommaso Giuliani, Javier Maupoey Ibáñez, Eva Montalvá-Orón, Andrea Boscà Robledo, Cristina Martínez Chicote, Ana Hernando Sanz, Cristina Ballester Ibañez, David Calatayud Mizrahi, Isabel Beneyto Castelló, Juan Francisco Merino Torres and 1 more

Abstract read
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In one paragraph

Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Tommaso GiulianiDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Javier Maupoey IbáñezDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Eva Montalvá-OrónDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Andrea Boscà RobledoDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Cristina Martínez ChicoteDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Ana Hernando SanzDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Cristina Ballester IbañezDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
David Calatayud MizrahiDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Isabel Beneyto CastellóDepartment of Nephrology and Kidney Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain.
Juan Francisco Merino TorresDepartment of Endocrinology, La Fe University Hospital and University of Valencia, Valencia, Spain.
Rafael López AndújarDepartment of HPB Surgery and Transplantation, La Fe University Hospital and University of Valencia, Valencia, Spain. rafaellopezandujar@gmail.com.
Hospital Universitari i Politècnic La Fe · ESUniversitat de València · ESInstituto de Investigación Sanitaria La Fe · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSimultaneous pancreas-kidney transplantation (SPK) is still characterized by high rates of postoperative complications. This study aims to offer an in-depth characterization of early, medium-term, and late complications following SPK to derive insights for postoperative management and follow-up.

methodsConsecutive SPK transplantations were analysed. Pancreatic graft (P-graft)- and kidney graft (K-graft)-related complications were analysed separately. The global postoperative course was assessed in three timeframes (early, medium-term, and late) using the comprehensive complication index (CCI). Predictors of complications and early graft loss were explored.

resultsComplications occurred in 61.2% of patients, and the 90-day mortality was 3.9%. The overall burden of complications was significantly high during admission (CCI 22.4 ± 21.1) and decreased gradually afterwards. P-graft-related complications burdened the most in the early postoperative course (CCI 11.6 ± 13.8); postoperative ileus and perigraft fluid collection were the most frequent complications, and pseudoaneurysms, haemorrhages, and bowel leaks were the major concerns. K-related complications were milder but represented the largest proportion of the CCI in the late postoperative timeframe (CCI 7.6 ± 13.6). No predictors of P-graft- or K-graft-related complications were found.

conclusionPancreas graft-related complications represent the largest part of the clinical burden in the early postoperative timeframe but are negligible after 3 months. Kidney grafts have a relevant impact in the long term. The multidisciplinary approach to SPK recipients should be driven based on all graft-specific complications and tailored on a time-dependent basis.

Indexed as

Diabetes Mellitus, Type 1Kidney TransplantationPancreas TransplantationGraft SurvivalHumansPancreasPostoperative ComplicationsAverage complication burdenComplicationsComprehensive Complication indexKidney transplantationPancreas transplantation

Identifiers

PMID37191721
OpenAlexW4376643498

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.