Evidence map›Paper›PMID 37193152›Full record

ArticleAmerican journal of translational research2023

Study on the clinical efficacy of Mongolian medicine in the treatment of osteoarthritis.

Runa A, Rigenjiya Mu, Qizhu Wu, Latai Ga, Long Bai, Rigatai A, Lidao Bao, Lengge Si, Gula A

Open access · greenAbstract read
PubMed Full text at PMC
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Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Runa AMongolian Traditional Therapy Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Rigenjiya MuMongolian Traditional Therapy Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Qizhu WuMongolian Medical Orthopedics Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Latai GaMongolian Medical Orthopedics Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Long BaiMongolian Traditional Therapy Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Rigatai ARehabilitation Department, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot, Inner Mongolia, China.
Lidao BaoPharmacy Department, Affiliated Hospital of Inner Mongolia Medical University Hohhot, Inner Mongolia, China.
Lengge SiMongolian Traditional Therapy Teaching and Research Section, Mongolian Medicine School, Inner Mongolian Medical University Hohhot, Inner Mongolia, China.
Gula ACollege of Traditional Chinese Medicine, Baotou Medical College Baotou, Inner Mongolia, China.
Inner Mongolia Medical University · CNBaotou Medical College · CNSecond Affiliated Hospital of Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe object of this paper was to evaluate the clinical efficacy and safety of Mongolian medicine in the treatment of osteoarthritis (OA). This was completed by offering evidence to provide a clinical basis for the treatment of OA. We explored the mechanism of the sticking application of Mongolian medicine.

methodA total of 123 patients with OA diagnosed in the Affiliated Hospital of Inner Mongolia Medical University from January 2017 to December 2017 were enrolled. The clinical data of the patients were retrospectively analyzed. Patients were divided into three groups according to the medication they were using at the time: The strapping group, the glucosamine hydrochloride group, and the Mongolian medicine group, with 41 patients in each group. The treatment indicators of the included patients 2 weeks after the treatment and 4 weeks after the treatment were fully recorded in our hospital. The levels of CGRP, TNF-α, MMP-3, VEGF, and IL-10 before and after treatment were measured by ELISA. The auxiliary diagnostic index was X-ray film.

resultsCompared with the control group, the Mongolian medicine group improved the symptoms of pain, swelling, limited movement, and daily life quality of patients to different degrees. There was a significant decrease in the VAS score at each time point of the Mongolian medicine group (P < 0.05). tThe scores of bodily pain in SF-36 QOL were significantly higher in the Mongolian medicine group at different time points (P < 0.05). After treatment, the levels of MMP-3, TNF-α, VEGF, and CGRP in the Mongolian medicine group were significantly lower than those before the treatment (P < 0.05).

conclusionMongolian medicine can inhibit the expression of MMP-3, TNF-α, VEGF, and CGRP in serum, and up-regulate the trend of IL-10, alleviating the inflammatory reaction. It has a good curative effect in the treatment of OA patients. It is better than western medicine in pain, swelling, and improving bone and joint function index.

Indexed as

Mongolian medicineosteoarthritisrandomized contrastWOMAC pain score

Identifiers

PMID37193152
PMCPMC10182510
OpenAlexW4376872731

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.