ArticleAmerican journal of translational research2023
Effect of dexmedetomidine on postoperative cognitive dysfunction and the T helper 17/regulatory T cell balance in geriatric patients undergoing orthopedic surgery: a randomized controlled study.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- Regulatory T cells in perioperative neurocognitive disorders: a systematic review with structured narrative synthesis from molecular mechanisms to clinical translation.Frontiers in molecular neuroscience · 2026Pooled it
- Efficacy of perioperative dexmedetomidine in postoperative pain and neurocognitive functions in orthopedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.International journal of surgery (London, England) · 2025Pooled it
- Perioperative neurocognitive disorders as a neuroimmune landscape disorder: microglial priming, state heterogeneity, and time-dependent neuroinflammation.Frontiers in immunology · 2026Review
- Microglial PGC-1α alleviates synaptic damage and cognitive impairments following anesthesia and surgery by suppressing excessive synaptic pruning in aged mice.International journal of biological sciences · 2026Article
- Impact of dexmedetomidine on postoperative cognitive dysfunction and inflammatory response in older adult female patients undergoing laparoscopic cholecystectomy.Frontiers in surgery · 2025Article
- Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation.Brain, behavior, and immunity · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the effect of dexmedetomidine (DEX) on alleviating postoperative cognitive dysfunction (POCD) and T helper 17 (Th17)/regulatory T cell (Treg) imbalance in geriatric patients undergoing orthopedic surgery.
methodsA total of 82 geriatric patients undergoing lower extremity joint replacement surgery were enrolled and randomized into two groups. Patients in the experimental group received a loading dose of 0.5 µg/kg DEX for 10 min and then a maintenance dose of 0.5 µg/kg/h DEX until 30 min before the end of the surgery, while patients in the control group were administered with an equal volume of saline. The mini-mental state examination (MMSE) was used to evaluate the patients' cognitive function levels. The enzyme-linked immunosorbent assay (ELISA) was used to detect the protein levels of S100 calcium-binding protein B (S-100β), matrix metalloproteinase 9 (MMP9), interleukin-10 (IL-10) and interleukin-17A (IL-17A). The quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect and compare the mRNA levels of retinoic acid-related orphan receptor gamma-t (RORγt) and forkhead box P3 (Foxp3), the ratio of which reflected Th17/Treg balance.
resultsCompared to the control group, the MMSE scores in the DEX group were obviously higher at 24 and 72 h after the surgery, and the incidence of POCD was lower in the DEX group. Simultaneously, DEX significantly decreased the level of S100β, MMP9, and the ratio of RORγt/Foxp3 mRNA at the end of the surgery and one day after surgery. Furthermore, IL-10 was upregulated, while the IL-17A and the IL-17A/IL-10 ratio were downregulated at the end of the surgery and one day after surgery in the DEX group.
conclusionsDEX could reduce the incidence of POCD in elderly orthopedic patients, which might be related to the attenuation of inflammatory response and blood-brain barrier (BBB) damage through modulating the Th17/Treg imbalance.
Indexed as
Identifiers
37193172PMC10182492W4376871969What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.