Evidence map›Paper›PMID 37197029›Full record

ArticlebioRxiv : the preprint server for biology2023

A TNF-IL-1 circuit controls

Rina Matsuda, Daniel Sorobetea, Jenna Zhang, Stefan T Peterson, James P Grayczyk, Beatrice Herrmann, Winslow Yost, Rosemary O'Neill, Andrea C Bohrer, Matthew Lanza and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Rina MatsudaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Daniel SorobeteaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Jenna ZhangDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Stefan T PetersonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
James P GrayczykDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Beatrice HerrmannDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Winslow YostDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Rosemary O'NeillDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Andrea C BohrerInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Matthew LanzaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Charles-Antoine AssenmacherDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sunny ShinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.ORCID 0000-0001-5214-9577
Igor E BrodskyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.ORCID 0000-0001-7970-872X
University of Pennsylvania · USNational Institutes of Health · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Innate immune-mediated control of pulmonary Legionella pneumophila infectionR01AI118861 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2025
$4.6M
Defining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0M
Lymphothrombosis in gut health and diseaseR01DK123528 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E, KAHN, MARK L · 2019 to 2023
$2.0M
Defining human noncanonical inflammasome responses to Legionella pneumophilaR01AI123243 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2020
$2.0M
Training in Microbial Pathogenesis and GenomicsT32AI141393 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D, ZHU, JUN · 2019 to 2023
$1.3M
TNF and caspase-8-mediated control of Legionella pneumophila infectionR21AI151476 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2021 to 2022
$447k
Aperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis SoftwareS10OD023465 · OD · UNIVERSITY OF PENNSYLVANIA · PI DURHAM, AMY CLEVELAND · 2018 to 2018
$329k
Dissecting Innate Immune Responses to Salmonella EnteritidisF31AI161319 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERRMANN, BEATRICE · 2021 to 2023
$128k
Defining Mechanisms of NAIP5-independent Flagellin Sensing during Bacterial InfectionF32AI164655 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GRAYCZYK, JAMES · 2021 to 2022
$100k
Intestinal granuloma formation during Yersinia pseudotuberculosis infectionF31AI160741 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MATSUDA, RINA · 2021 to 2023
$99k
NCI NIH HHS P30 CA016520NIAID NIH HHS F31 AI160741NIAID NIH HHS F31 AI161319NIAID NIH HHS F32 AI164655NIAID NIH HHS R01 AI118861NIAID NIH HHS R01 AI123243NIAID NIH HHS R01 AI128530NIAID NIH HHS R21 AI151476NIAID NIH HHS T32 AI141393NIDDK NIH HHS R01 DK123528NIH HHS S10 OD023465
6 · The paper itself

Abstract

Tumor necrosis factor (TNF) is a pleiotropic inflammatory cytokine that mediates antimicrobial defense and granuloma formation in response to infection by numerous pathogens.

Identifiers

PMID37197029
PMCPMC10176537
OpenAlexW4366782685

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.