Evidence map›Paper›PMID 37202200›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Enhanced endoplasmic reticulum RyR1 receptor phosphorylation leads to diaphragmatic dysfunction in septic rats].

S Wu, X Li, F Guan, J Feng, J Jia, J Li, L Liu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

S WuDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
X LiDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
F GuanDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
J FengDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
J JiaDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
J LiAnesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou 646000, China.
L LiuDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Southwest Medical University · CNAffiliated Hospital of Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of endoplasmic reticulum ryanodine receptor 1 (RyR1) expression and phosphorylation in sepsis- induced diaphragm dysfunction.

methodsThirty SPF male SD rats were randomized equally into 5 groups, including a sham-operated group, 3 sepsis model groups observed at 6, 12, or 24 h following cecal ligation and perforation (CLP; CLP-6h, CLP-12h, and CLP-24h groups, respectively), and a CLP-24h group with a single intraperitoneal injection of KN- 93 immediately after the operation (CLP-24h+KN-93 group). At the indicated time points, diaphragm samples were collected for measurement of compound muscle action potential (CMAP), fatigue index of the isolated diaphragm and fitted frequencycontraction curves. The protein expression levels of CaMK Ⅱ, RyR1 and P-RyR1 in the diaphragm were detected using Western blotting.

resultsIn the rat models of sepsis, the amplitude of diaphragm CMAP decreased and its duration increased with time following CLP, and the changes were the most obvious at 24 h and significantly attenuated by KN-93 treatment (

conclusionSepsis causes diaphragmatic dysfunction by enhancing CaMK Ⅱ expression and RyR1 receptor phosphorylation in the endoplasmic reticulum of the diaphragm.

Indexed as

DiaphragmSepsisAnimalsBenzenesulfonamidesBenzylaminesEndoplasmic ReticulumMaleMuscle ContractionPhosphorylationRatsRats, Sprague-DawleyRyanodine Receptor Calcium Release ChannelBenzenesulfonamidesBenzylaminesKN 93Ryanodine Receptor Calcium Release Channeldiaphragm dysfunctionmuscle weaknessphosphorylationRyR1sepsis

Identifiers

PMID37202200
PMCPMC10202788
OpenAlexW4377094634

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.