Evidence map›Paper›PMID 37202497›Full record

ArticleSports medicine - open2023

Exercise and Prediabetes After Renal Transplantation (EXPRED-I): A Prospective Study.

Raúl Morales Febles, Domingo Marrero Miranda, Alejandro Jiménez Sosa, Ana González Rinne, Coriolano Cruz Perera, Ana Elena Rodríguez-Rodríguez, Alejandra Álvarez González, Laura Díaz Martín, Natalia Negrín Mena, Cristian Acosta Sørensen and 10 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine - open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489043 (Exercise, Prediabetes and Diabetes After Renal Transplantation.), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489043 naunknown statusnot on this map

Exercise, Prediabetes and Diabetes After Renal Transplantation.

TypeinterventionalSponsorHospital Universitario de CanariasRan2019 to 2021Enrolled60ConditionsDiabetes MellitusArmsExercise and healthy lifestyle recommendations
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Raúl Morales Febles *Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain.
Domingo Marrero Miranda *Nephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Alejandro Jiménez SosaResearch Unit, University Hospital of Canary Islands, La Laguna, Spain.
Ana González RinneNephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Coriolano Cruz PereraResearch Unit, University Hospital of Canary Islands, La Laguna, Spain.
Ana Elena Rodríguez-RodríguezResearch Unit, University Hospital of Canary Islands, La Laguna, Spain.
Alejandra Álvarez GonzálezNephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Laura Díaz MartínResearch Unit, University Hospital of Canary Islands, La Laguna, Spain.
Natalia Negrín MenaResearch Unit, University Hospital of Canary Islands, La Laguna, Spain.
Cristian Acosta SørensenNephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Lourdes Pérez TamajónNephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Aurelio Rodríguez HernándezNephrology Department, University Hospital of Canary Islands, La Laguna, Spain.
Federico González RinneLaboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain.
Aday Dorta GonzálezFaculty of Physiotherapy, University of La Laguna, La Laguna, Spain.
Eusebio Ledesma PérezFaculty of Physiotherapy, University of La Laguna, La Laguna, Spain.
Alejandra González DelgadoCentral Laboratory, University Hospital of Canary Islands, La Laguna, Spain.
Alberto Domínguez-RodríguezCardiology Department, University Hospital of Canary Islands, La Laguna, Spain.
Maria Del Carmen García BauteCardiology Department, University Hospital of Canary Islands, La Laguna, Spain.
Armando Torres RamírezFaculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain.
Esteban PorriniFaculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain. estebanporrini72@hotmail.com.ORCID http://orcid.org/0000-0002-3056-4662
Universidad de La Laguna · ESHospital Universitario de Canarias · ES

Funding

Fundación Canaria de Investigación y Salud PIFIISC 20/49Instituto de Salud Carlos III FI 17/00303 (PFIS)
6 · The paper itself

Abstract

backgroundPost-transplant diabetes mellitus (PTDM) beyond 12 months (late PTDM) is a severe complication after renal transplantation. Late PTDM develops mostly in subjects with prediabetes. Although exercise may have a potential role in preventing late PTDM, there are no previous data on the effect of exercise in patients with prediabetes. MATERIAL AND

methodsThe design was a 12-month exploratory study to test the capacity of exercise in reverting prediabetes in order to prevent late-PTDM. The outcome was the reversibility of prediabetes, assessed every 3 months with oral glucose tolerance tests (OGTT). The protocol included an incremental plan of aerobic and/or strength training as well as an active plan for promoting adherence (telephone calls, digital technology, and visits). A priori, a sample size cannot be calculated which makes this an exploratory analysis. Based on previous studies, the spontaneous reversibility of prediabetes was 30% and the reversibility induced by exercise will account for another 30%, a total reversibility of 60% (p value < 0.05, assuming a potency of 85%). Ad interim analysis was performed during follow-up to test the certainty of this sample calculation. Patients beyond 12 months after renal transplantation with prediabetes were included.

resultsThe study was interrupted early due to efficacy after the evaluation of the follow-up of 27 patients. At the end of follow-up, 16 (60%) patients reverted to normal glucose levels at fasting (from 102.13 mg/dL ± 11 to 86.75 ± 6.9, p = 0.006) and at 120 min after the OGTTs (154.44 mg/dL ± 30 to 113.0 ± 13.1, p = 0.002) and 11 patients had persistent prediabetes (40%). Also, insulin sensitivity improved with the reversibility of prediabetes, compared to those with persistent prediabetes: 0.09 [0.08-0.11] versus 0.04 [0.01-0.07], p = 0.001 (Stumvoll index). Most needed at least one increment in the prescription of exercise and compliance. Finally, measures aimed at the improvement of compliance were successful in 22 (80%) patients.

conclusionExercise training was effective to improve glucose metabolism in renal transplant patients with prediabetes. Exercise prescription must be conducted considering both the clinical characteristics of the patients and pre-defined strategy to promote adherence. The trial registration number of the study was NCT04489043.

Indexed as

Exercise and adherencePost-transplant diabetes mellitusPrediabetesRenal transplantation

Identifiers

PMID37202497
PMCPMC10195924
OpenAlexW4377046960

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.