Evidence map›Paper›PMID 37203204›Full record

ArticlePharmaceutical biology2023

Identification of natural compound garcinone E as a novel autophagic flux inhibitor with anticancer effect in nasopharyngeal carcinoma cells.

Dan Wei, Luolin Wang, Shunmei Lei, Han Zhang, Caihua Dong, Yao Ke, Yuting Su, Xiaoying Chen, Lianping Xia, Xiaoyang Kong and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Dan WeiKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Luolin WangDepartment of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, P.R. China.
Shunmei LeiKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Han ZhangKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Caihua DongKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Yao KeKey Laboratory of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China).
Yuting SuKey Laboratory of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China).
Xiaoying ChenKey Laboratory of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China).
Lianping XiaKey Laboratory of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China).
Xiaoyang KongKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Fuqiang YinKey Laboratory of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China).
Xia LiuKey Laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education, Center for Translational Medicine and School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, P.R. China.
Guangxi Medical University · CNGuangxi University · CNSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextCurrent chemotherapeutic drugs cannot meet the treatment needs of patients with nasopharyngeal carcinoma (NPC), so urgent action is needed to discover novel chemotherapeutic agents. Our previous study revealed that garcinone E (GE) inhibited the proliferation and metastasis of NPC, suggesting that the compound might display promising anticancer activity.

objectiveTo examine the mechanism underlying the anti-NPC activity of GE for the first time. MATERIALS AND

methodsFor MTS assay, NPC cells were treated with 2.5-20 μmol/L GE or dimethyl sulfoxide for 24, 48, and 72 h. Colony formation capacity, cell cycle distribution, and

resultsGE suppressed cell viability with an IC DISCUSSION AND

conclusionGE acts as an autophagic flux inhibitor, which may have potential chemotherapeutic use for NPC treatment and may have an application in basic research to explore the mechanisms of autophagy.

Indexed as

ApoptosisNasopharyngeal NeoplasmsAutophagyCell Line, TumorCell ProliferationHumansNasopharyngeal CarcinomaXanthenesgarcinone EXanthenesautophagosomeAutophagycell cycle arrestKEGG pathway enrichmentRNA-seq

Identifiers

PMID37203204
PMCPMC10202006
OpenAlexW4377093808

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.