Evidence map›Paper›PMID 37204656›Full record

ArticleHepatology international2023

An international multidisciplinary consensus statement on MAFLD and the risk of CVD.

Xiao-Dong Zhou, Giovanni Targher, Christopher D Byrne, Virend Somers, Seung Up Kim, C Anwar A Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D Shapiro, Mohammed Eslam and 38 more

Open access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Hepatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 4 pooled it
36.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.

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  10. From abdominal adiposity to liver fibrosis: Expanding promise of semaglutide for Asian Indians.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 29 countries.

Xiao-Dong Zhou *Department of Cardiovascular Medicine, The Heart Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Giovanni Targher *Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Verona, Verona, Italy.
Christopher D Byrne *Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, and University of Southampton, Southampton General Hospital, Southampton, UK.
Virend SomersDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, USA.
Seung Up KimDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea.
C Anwar A ChahalDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, USA.
Vincent Wai-Sun WongState Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
Jingjing CaiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mohammed EslamStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, NSW, 2145, Australia.
Philippe Gabriel StegUniversité Paris -Cité, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris, France.
Ki-Chul SungDepartment of Internal Medicine, Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Anoop MisraFortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, National Diabetes Obesity and Cholesterol Foundation and Diabetes Foundation (India), New Delhi, India.
Jian-Jun LiState Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Carlos BrotonsBiomedical Research Institute Sant Pau (IIB Sant Pau), Sardenya Primary Health Care Center, Barcelona, Spain.
Yuli HuangDepartment of Cardiology, Shunde Hospital, Southern Medical University, Jiazi Road, Lunjiao Town, Shunde District, Foshan, China.
George V PapatheodoridisDepartment of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Athens, Greece.
Aijun SunShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Yusuf YilmazInstitute of Gastroenterology, Marmara University, Istanbul, Turkey.
Wah Kheong ChanGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Hui HuangDepartment of Cardiology, The Eighth Affiliated Hospital of Sun Yat-Sen University, 3025 Shennan Middle Road, Shenzhen, China.
Nahum Méndez-SánchezLiver Research Unit, Medica Sur Clinic and Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Saleh A AlqahtaniLiver Transplantation Unit, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Helena Cortez-PintoLaboratório de Nutrição e Metabolismo, Faculdade de Medicina, Clínica Universitária de Gastrenterologia, Universidade de Lisboa, Lisbon, Portugal.
Gregory Y H LipLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK.
Robert J de KnegtDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Gravendijkwal 230, Room Ha 206, Rotterdam, The Netherlands.
Ponsiano OcamaDepartment of Internal Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Manuel Romero-GomezDepartment of Digestive and Liver Diseases, Institute of Biomedicine of Seville, University Hospital Virgen del Rocio, University of Seville, Seville, Spain.
Marat FudimDepartment of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Giada SebastianiDivision of Gastroenterology and Hepatology, Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, 1001 Blvd. Décarie, Montreal, Canada.
Jang Won SonDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
John D RyanDepartment of Hepatology, RCSI School of Medicine and Medical Sciences, Dublin/Beaumont Hospital, Dublin, Ireland.
Ignatios IkonomidisPreventive Cardiology Laboratory and Cardiometabolic Clinic, Second Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Sombat TreeprasertsukDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Daniele PastoriDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Monica Lupsor-PlatonDepartment of Medical Imaging, "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepathology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.
Hasmik GhazinyanDepartment of Hepatology, Nork Clinical Hospital of Infectious Disease, Yerevan, Armenia.
Jerome BoursierHepato-Gastroenterology Department, University Hospital, 4 Larrey Street, 49933, Angers Cedex 09, France.
Masahide HamaguchiDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, Japan.
Mindie H NguyenDivision of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.
Jian-Gao FanCenter for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
George Boon-Bee GohDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
Mamun Al MahtabDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Saeed HamidDepartment of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan.
Nilanka PereraDepartment of Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, NSW, 2145, Australia. jacob.george@sydney.edu.au.
Ming-Hua ZhengMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Fuxue Lane, Wenzhou, 325000, China. zhengmh@wmu.edu.cn.ORCID http://orcid.org/0000-0003-4984-2631
National and Kapodistrian University of Athens · GRSun Yat-sen University · CNThe University of Sydney · AUWenzhou Medical University · CNAga Khan University · PKBangladesh Medical University · BDBeaumont Hospital · IECatholic University of Korea · KRCentral South University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese University of Hong Kong · HKDuke University · USErasmus MC · NLHospital Médica Sur · MXInnsbruck Medical University · ATInserm · FRInstituto de Biomedicina de Sevilla · ESIuliu Hațieganu University of Medicine and Pharmacy · ROJohns Hopkins University · USKangbuk Samsung Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 diabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease, the CVD risk associated with MAFLD is often underestimated, especially among Cardiologists. METHODS AND

resultsA multidisciplinary panel of fifty-two international experts comprising Hepatologists, Endocrinologists, Diabetologists, Cardiologists and Family Physicians from six continents (Asia, Europe, North America, South America, Africa and Oceania) participated in a formal Delphi survey and developed consensus statements on the association between MAFLD and the risk of CVD. Statements were developed on different aspects of CVD risk, ranging from epidemiology to mechanisms, screening, and management. CONCULSIONS: The expert panel identified important clinical associations between MAFLD and the risk of CVD that could serve to increase awareness of the adverse metabolic and cardiovascular outcomes of MAFLD. Finally, the expert panel also suggests potential areas for future research.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Liver DiseasesNon-alcoholic Fatty Liver DiseaseAsiaConsensusHumansCardiovascular diseaseConsensusDelphi surveyMAFLDMetabolic (dysfunction)-associated fatty liver diseaseNon-alcoholic fatty liver disease

Identifiers

PMID37204656
PMCPMC10198034
OpenAlexW4377090407

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.