Evidence map›Paper›PMID 37205334›Full record

ArticlebioRxiv : the preprint server for biology2023

Calcium-triggered DNA-mediated membrane fusion in synthetic cells.

Yen-Yu Hsu, Samuel J Chen, Julio Bernal-Chanchavac, Bineet Sharma, Hossein Moghimianavval, Nicholas Stephanopoulos, Allen P Liu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yen-Yu HsuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Samuel J ChenDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Julio Bernal-ChanchavacSchool of Molecular Sciences, Arizona State University, Tempe, Arizona, USA.
Bineet SharmaDepartment of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey, USA.
Hossein MoghimianavvalDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Nicholas StephanopoulosSchool of Molecular Sciences, Arizona State University, Tempe, Arizona, USA.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · USArizona State University · USRutgers, The State University of New Jersey · US

Funding

Chemical synthesis of G protein-coupled receptors using sequential DNA-templated reactionsDP2GM132931 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI STEPHANOPOULOS, NICHOLAS · 2018 to 2018
$2.2M
Development of a mechanosensitive synthetic cell for mediating intercellular communication - Diversity SupplementR01EB030031 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, ALLEN PO-CHIH · 2020 to 2024
$1.3M
NIBIB NIH HHS R01 EB030031NIGMS NIH HHS DP2 GM132931
6 · The paper itself

Abstract

In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

Identifiers

PMID37205334
PMCPMC10187331
OpenAlexW4372328845

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.