Evidence map›Paper›PMID 37205391›Full record

ArticleResearch square2023

Novel Populations of Lung Capillary Endothelial Cells and Their Functional Significance.

Joel James, Aleksandr Dekan, Maki Niihori, Nolan McClain, Mathews Varghese, Dinesh Bharti, Odunayo Susan Lawal, Marco Padilla-Rodrigez, Dan Yi, Zhiyu Dai and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Joel JamesUniversity of Arizona.
Aleksandr DekanUniversity of Arizona.
Maki NiihoriUniversity of Arizona.
Nolan McClainUniversity of Arizona.
Mathews VargheseUniversity of Arizona.
Dinesh BhartiUniversity of Arizona.
Odunayo Susan LawalUniversity of Arizona.
Marco Padilla-RodrigezUniversity of Arizona.
Dan YiUniversity of Arizona.
Zhiyu DaiUniversity of Arizona.
Oleg GusevJuntendo University.
Olga RafikovaUniversity of Arizona.
Ruslan RafikovUniversity of Arizona.
University of Arizona · USJuntendo University Hospital · JP

Funding

Anaplerotic reprogramming of endothelial cells in pulmonary hypertension.R01HL132918 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOV, RUSLAN · 2016 to 2025
$4.5M
Hemolysis and Free Heme Signaling in Pulmonary HypertensionR01HL151447 · NHLBI · UNIVERSITY OF ARIZONA · PI Ruslan Rafikov · 2020 to 2026
$4.3M
Mitochondrial Dysfunction in Pulmonary HypertensionR01HL160666 · NHLBI · UNIVERSITY OF ARIZONA · PI Olga Rafikova · 2022 to 2026
$3.3M
Role of Endothelial SOX17 Deficiency in the Pathogenesis of Pulmonary HypertensionR01HL158596 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2022 to 2026
$2.3M
Fatty acid-binding proteins sustain endothelial glycolysis and arterial programming in pulmonary arterial hypertensionR01HL162794 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2023 to 2026
$2.3M
HMGBG1 and Gender Difference in Pulmonary Arterial HypertensionR01HL133085 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOVA, OLGA · 2016 to 2020
$1.9M
NHLBI NIH HHS R01 HL132918NHLBI NIH HHS R01 HL133085NHLBI NIH HHS R01 HL151447NHLBI NIH HHS R01 HL158596NHLBI NIH HHS R01 HL160666NHLBI NIH HHS R01 HL162794
6 · The paper itself

Abstract

The role of the lung's microcirculation and capillary endothelial cells in normal physiology and the pathobiology of pulmonary diseases is unequivocally vital. The recent discovery of molecularly distinct aerocytes and general capillary (gCaps) endothelial cells by single-cell transcriptomics (scRNAseq) advanced the field in understanding microcirculatory milieu and cellular communications. However, increasing evidence from different groups indicated the possibility of more heterogenic structures of lung capillaries. Therefore, we investigated enriched lung endothelial cells by scRNAseq and identified five novel populations of gCaps with distinct molecular signatures and roles. Our analysis suggests that two populations of gCaps that express Scn7a(Na

Indexed as

endotheliumgeneral capillarymicrocirculationpulmonary circulationsingle cell analysis

Identifiers

PMID37205391
PMCPMC10187412
OpenAlexW4367836753

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.