Evidence map›Paper›PMID 37205445›Full record

ArticlebioRxiv : the preprint server for biology2023

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.

Natalia A Veniaminova, Yunlong Jia, Adrien M Hartigan, Thomas J Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A Dlugosz, Scott X Atwood, Sunny Y Wong

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Natalia A VeniaminovaDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Yunlong JiaDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Adrien M HartiganDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas J HuygeDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Shih-Ying TsaiDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Marina GrachtchoukDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Seitaro NakagawaDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Andrzej A DlugoszDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Scott X AtwoodDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Sunny Y WongDepartment of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USUniversity of California, Irvine · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
The Hair Follicle Infundibulum: A Potential Mediator of Skin Barrier FunctionR01AR065409 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sunny Y Wong · 2014 to 2026
$3.8M
Exploring hair follicle-associated functions in normal and ichthyotic skinR01AR080654 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sunny Y Wong · 2022 to 2026
$2.0M
NCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR065409NIAMS NIH HHS R01 AR080654
6 · The paper itself

Abstract

Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs are largely self-renewed by dedicated stem cell pools during homeostasis. Using targeted single cell RNA-sequencing, we uncovered both direct and indirect paths by which these resident SG progenitors ordinarily differentiate into sebocytes, including transit through a PPARγ+Krt5+ transitional cell state. Upon skin injury, however, SG progenitors depart their niche, reepithelialize the wound, and are replaced by hair follicle-derived stem cells. Furthermore, following targeted genetic ablation of >99% of SGs from dorsal skin, these glands unexpectedly regenerate within weeks. This regenerative process is mediated by alternative stem cells originating from the hair follicle bulge, is dependent upon FGFR signaling, and can be accelerated by inducing hair growth. Altogether, our studies demonstrate that stem cell plasticity promotes SG durability following injury.

Identifiers

PMID37205445
PMCPMC10187279
OpenAlexW4372183526

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.