Evidence map›Paper›PMID 37206213›Full record

ReviewBioengineering & translational medicine2023

Biomimetic nanotherapeutics for targeted drug delivery to glioblastoma multiforme.

Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo, Wai-Cheong George Yip, Alan Prem Kumar, Daniel Boon Loong Teh

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xin Yuan LimMBBS Programme Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0001-5088-8130
Sharah Mae CapinpinDepartment of Pharmacology Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0001-6759-1712
Nagarjun BolemDepartment of Surgery, Division of Neurosurgery National University Hospital Singapore Singapore.ORCID https://orcid.org/0000-0002-0225-5299
Aaron Song Chuan FooMBBS Programme Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0002-7598-8127
Wai-Cheong George YipDepartment of Anatomy Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0003-0152-0510
Alan Prem KumarDepartment of Pharmacology Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0002-3754-5712
Daniel Boon Loong TehDepartment of Anatomy Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore.ORCID https://orcid.org/0000-0002-4560-8568
National University of Singapore · SGNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis and high mortality, with no curative treatment to date as limited trafficking across the blood-brain barrier (BBB) combined with tumor heterogeneity often leads to therapeutic failure. Although modern medicine poses a wide range of drugs that are otherwise efficacious in treating other tumors, they often do not achieve therapeutic concentrations in the brain, hence driving the need for more effective drug delivery strategies. Nanotechnology, an interdisciplinary field, has been gaining immense popularity in recent years for remarkable advancements such as nanoparticle (NP) drug carriers, which possess extraordinary versatility in modifying surface coatings to home in on target cells, including those beyond the BBB. In this review, we will be highlighting recent developments in biomimetic NPs in GBM therapy and how these allowed us to overcome the physiological and anatomical challenges that have long plagued GBM treatment.

Indexed as

biomimeticglioblastomananoparticlenanotechnology

Identifiers

PMID37206213
PMCPMC10189489
OpenAlexW4320921136

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.