Evidence map›Paper›PMID 37206382›Full record

ArticleChemical science2023

Synthesis of biolabile thioalkyl-protected phosphates from an easily accessible phosphotriester precursor.

Lloyd D Murphy, Kathryn E Huxley, Ava Wilding, Cyane Robinson, Quentin P O Foucart, Lianne I Willems

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Probing Glycerolipid Metabolism using a Caged Clickable Glycerol-3-Phosphate Probe.Chembiochem : a European journal of chemical biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lloyd D MurphyYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York York YO10 5DD UK lianne.willems@york.ac.uk.ORCID https://orcid.org/0000-0002-6129-292X
Kathryn E HuxleyYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York York YO10 5DD UK lianne.willems@york.ac.uk.
Ava WildingDepartment of Chemistry, University of York York YO10 5DD UK.
Cyane RobinsonDepartment of Chemistry, University of York York YO10 5DD UK.
Quentin P O FoucartYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York York YO10 5DD UK lianne.willems@york.ac.uk.ORCID https://orcid.org/0009-0006-8879-2357
Lianne I WillemsYork Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York York YO10 5DD UK lianne.willems@york.ac.uk.ORCID https://orcid.org/0000-0001-5411-1329
University of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robust methods for the synthesis of mixed phosphotriesters are essential to accelerate the development of novel phosphate-containing bioactive molecules. To enable efficient cellular uptake, phosphate groups are commonly masked with biolabile protecting groups, such as

Identifiers

PMID37206382
PMCPMC10189884
OpenAlexW4366402928

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.