Evidence map›Paper›PMID 37207206›Full record

ArticleFrontiers in immunology2023

Effects of HLA single chain trimer design on peptide presentation and stability.

Kathryn A K Finton, Peter B Rupert, Della J Friend, Ana Dinca, Erica S Lovelace, Matthew Buerger, Domnita V Rusnac, Ulysses Foote-McNabb, William Chour, James R Heath and 3 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kathryn A K FintonDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Peter B RupertDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Della J FriendDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Ana DincaClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Erica S LovelaceDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Matthew BuergerDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Domnita V RusnacDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
Ulysses Foote-McNabbDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.
William ChourInstitute for Systems Biology, Seattle, WA, United States.
James R HeathInstitute for Systems Biology, Seattle, WA, United States.
Jean S CampbellClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Robert H PierceClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Roland K StrongDivision of Basic Science, Fred Hutchinson Cancer Research Center (FHCC), Seattle, WA, United States.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Deeply analyzing MHC class I-restricted peptide presentation mechanistics across alleles, pathways, and disease coupled with TCR discovery/characterizationR01AI176563 · NIAID · FRED HUTCHINSON CANCER CENTER · PI Roland K Strong · 2023 to 2026
$3.2M
TCR-like antibodies for HPV-induced cancer basic research and theranosticsR01AI121242 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STRONG, ROLAND K · 2016 to 2019
$1.7M
Acquisition of a Rigaku XtaLAB Synergy-R macromolecular diffraction instrumentation at Fred Hutchinson Cancer Research CenterS10OD028581 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STODDARD, BARRY L. · 2020 to 2020
$600k
NCI NIH HHS P30 CA015704NIAID NIH HHS R01 AI121242NIAID NIH HHS R01 AI176563NIH HHS S10 OD028581
6 · The paper itself

Abstract

MHC class I "

Indexed as

Histocompatibility Antigens Class IPeptidesAnimalsEpitopesHumansMiceEpitopesHistocompatibility Antigens Class IPeptidesHLA single-chain trimershuman class I leukocyte antigenspan-anti-class I antibodiespeptide presentationX-ray crystallography

Identifiers

PMID37207206
PMCPMC10189100

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.