ArticleInternational journal of obesity (2005)2023
Association between BMI, RFM and mortality and potential mediators: Prospective findings from the Moli-sani study.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Erector spinae muscle characteristics predict 90-day survival in elderly pneumonia patients.Scientific reports · 2026Observational
- Relative fat mass and cardiovascular risk in Chinese adults: a nationwide prospective cohort study.Nutrition journal · 2025Article
- A comparison of anthropometric indicators in predicting the incidence of diabetes and intermediate hyperglycaemia in Finland: a 22-year observational study.BMC public health · 2025Observational
- Association between erectile dysfunction and relative fat mass in adult men in the United States.Translational andrology and urology · 2025Article
- Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation.European journal of clinical investigation · 2025Review
- Adiposity indices mediate the association between dietary inflammatory index and type 2 diabetes risk in women with prior gestational diabetes mellitus.Diabetology & metabolic syndrome · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Association Between Relative Fat Mass and the Serum Creatinine/Cystatin C Ratio and Cardiometabolic Multimorbidity: Evidence From Two Large Population-Based Surveys.Journal of diabetes research · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality.Scientific reports · 2024Article
- Association between relative fat mass and kidney stones in American adults.Scientific reports · 2024Article
- Article
- Relative Fat Mass, A Better Predictor of Erectile Dysfunction: Insights From the NHANES 2001-2004.American journal of men's healthArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBody mass index (BMI) is the most frequently used adiposity measure, yet it is unable to differentiate fat mass from lean mass. Relative fat mass (RFM) has been proposed as an alternative. This paper aims to study RFM and BMI association with mortality in a general Italian population and potential mediators of such association.
methods20,587 individuals from the Moli-sani cohort were analysed (mean age = 54 ± 11, women = 52%, median follow up = 11.2 years, interquartile range = 1.96 years). Cox regressions were used to assess BMI, RFM, and their interactive association with mortality. Dose-response relationships were computed with spline regression, mediation analysis was performed. All analyses were separated for men and women.
resultsMen and women with BMI > 35 kg/m
conclusionsThe association between anthropometric measures and mortality was U shaped and it was largely dependent on sex. Associations were mediated by glucose metabolism, renal and lung function. Public health interventions should mainly focus on people with severe obesity or impaired metabolic, renal, or respiratory function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.