ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multi-Centre Reproducibility of DTI and NODDI in White Matter Tracts Segmented Using TractFinder Across Three MRI Scanners of the Same Model.Human brain mapping · 2026Article
- Exploratory study of peripheral immune changes associated with diffusion MRI multi-compartment model in temporal lobe epilepsy.Epilepsia · 2025Article
- Assessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies.Scientific reports · 2025Article
- White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures.NeuroImage. Clinical · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
background and purposeThe aim of this study was to assess the repeatability of neurite orientation dispersion and density imaging in healthy controls (HCs) and traumatic brain injury (TBI).
methodsSeventeen HCs and 48 TBI patients were scanned twice over 18 weeks with diffusion imaging. Orientation dispersion (ODI), neurite density (NDI), and the fraction of isotropic diffusion (F-ISO) were quantified in regions of interest (ROIs) from a gray matter, subcortical, and white matter atlas and compared using the coefficient of variation for repeated measures (CV
resultsNDI exhibited excellent repeatability in both groups; the only group difference was found in the fusiform gyrus, where HCs exhibited better repeatability (M-SLRT = 9.463, p = .0021). ODI also had excellent repeatability in both groups, although repeatability was significantly better in HCs in 16 cortical ROIs (p < .0022) and in the bilateral white matter and bilateral cortex (p < .0027). F-ISO exhibited relatively poor repeatability in both groups, with few group differences.
conclusionOverall, the repeatability of the NDI, ODI, and F-ISO metrics over an 18-week period is acceptable for assessing the effects of behavioral or pharmacological interventions, though caution is advised when assessing F-ISO changes over time.
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