Evidence map›Paper›PMID 37214930›Full record

ArticlebioRxiv : the preprint server for biology2025

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling.

Noah D Carrillo, Mo Chen, Tianmu Wen, Poorwa Awasthi, Trevor J Wolfe, Colin Sterling, Vincent L Cryns, Richard A Anderson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 14 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Noah D CarrilloORCID 0000-0002-1914-1095
Mo ChenORCID 0000-0002-3274-5889
Tianmu Wen
Poorwa Awasthi
Trevor J WolfeORCID 0000-0003-1021-7441
Colin SterlingORCID 0009-0004-5930-1112
Vincent L CrynsORCID 0000-0003-0355-2268
Richard A AndersonORCID 0000-0001-6265-8359
University of Wisconsin–Madison · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

Phosphoinositide Signaling in the Cytosol and NucleusR35GM134955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson · 2020 to 2026
$5.0M
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor ProgressionR01CA286492 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson, VINCENT L. CRYNS · 2024 to 2026
$2.8M
NCI NIH HHS R01 CA286492NIGMS NIH HHS R35 GM134955
6 · The paper itself

Abstract

Phosphoinositide (PIP Significance statement: PI transfer proteins and a PI 4-kinase initiate nuclear p53-phosphoinositide signaling in membrane-free regions to promote stress resistance.

Identifiers

PMID37214930
PMCPMC10197520
OpenAlexW4375947447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.