Evidence map›Paper›PMID 37216537›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The autism-associated loss of δ-catenin functions disrupts social behavior.

Hadassah Mendez-Vazquez, Regan L Roach, Kaila Nip, Soham Chanda, Matheus F Sathler, Tyler Garver, Rosaline A Danzman, Madeleine C Moseley, Jessica P Roberts, Olivia N Koch and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. American ginseng (Journal of ginseng research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Roles of AMPA receptors in social behaviors.Frontiers in synaptic neuroscience · 2024
    Review
  11. Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hadassah Mendez-VazquezDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-7421-4947
Regan L RoachDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Kaila NipCellular and Molecular Biology Program, Colorado State University Fort Collins CO 80523.
Soham ChandaCellular and Molecular Biology Program, Colorado State University Fort Collins CO 80523.ORCID 0000-0002-2327-6224
Matheus F SathlerDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Tyler GarverMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, CO 80523.
Rosaline A DanzmanDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Madeleine C MoseleyMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, CO 80523.
Jessica P RobertsMolecular, Cellular and Integrative Neurosciences Program, Colorado State University, Fort Collins, CO 80523.
Olivia N KochDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Ava A StegerRocky Mountain High School, Fort Collins, CO 80526.
Rahmi LeeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Jyothi ArikkathDevelopmental Neuroscience, Munore-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198.
Seonil KimDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-0451-2180
Colorado State University · USNebraska Medical Center · USRocky Mountain Research Station · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Cellular Mechanisms of Neuroligin-4 Gene in Human NeuronsR01MH126017 · NIMH · COLORADO STATE UNIVERSITY · PI Soham Chanda · 2022 to 2026
$1.8M
Recovery of Synaptic Dysfunction and Memory Loss in Alzheimer's Disease by Selective Co-Activation of Nicotinic Acetylcholine ReceptorsR03AG072102 · NIA · COLORADO STATE UNIVERSITY · PI KIM, SEONIL · 2021 to 2022
$304k
NCATS NIH HHS UL1 TR002535NIA NIH HHS R03 AG072102NIMH NIH HHS R01 MH126017
6 · The paper itself

Abstract

δ-catenin is expressed in excitatory synapses and functions as an anchor for the glutamatergic AMPA receptor (AMPAR) GluA2 subunit in the postsynaptic density. The glycine 34 to serine (G34S) mutation in the

Indexed as

Autism Spectrum DisorderAutistic DisorderDelta CateninAnimalsGlycogen Synthase Kinase 3 betaHumansMiceMice, KnockoutSocial BehaviorSynapsesDelta CateninGlycogen Synthase Kinase 3 betaAMPA receptorsautismdelta-cateninsocial behavior

Identifiers

PMID37216537
PMCPMC10235948
OpenAlexW4377291235

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.