Evidence map›Paper›PMID 37219048›Full record

ReviewCell transplantation

Neuronal Transplantation for Alzheimer's Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation.

Phoebe Strell, Sether T Johnson, Chris Carchi, Walter C Low

Open access · goldAbstract readReview
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Phoebe StrellDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1700-015X
Sether T JohnsonStem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
Chris CarchiStem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
Walter C LowDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8593-0175
University of Minnesota · US

Funding

Generating Exogenic Organs for Transplantation without the Use of ImmunosuppressionR01AI173804 · NIAID · UNIVERSITY OF MINNESOTA · PI WALTER C LOW, CLIFFORD John STEER · 2022 to 2026
$3.7M
NIAID NIH HHS R01 AI173804
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and restore neuronal cell function has previously been explored in AD animal models, yet most of these transplantation methods have utilized primary cell cultures or donor grafts. Blastocyst complementation offers a novel approach to generate a renewable exogenic source of neurons. These exogenic neurons derived from stem cells would develop with the

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesAnimalsBrainDisease Models, AnimalNeuronsAlzheimer’s diseaseblastocyst complementationgenes for neurodevelopmentinterspecies organogenesisneuronal transplantation

Identifiers

PMID37219048
PMCPMC10214098
OpenAlexW4377565601

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.