Evidence map›Paper›PMID 37219642›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2023

Evaluation of correlation between Diopsys® NOVA™ fixed-luminance flicker ERG and Diagnosys® Espion 2™ flicker ERG parameters.

Jonathan Regenold, Hien Luong Doan, Hashem Ghoraba, Hassan Khojasteh, Jaclyn Joyce Jaclyn Hwang, Negin Yavari, Amir Akhavanrezayat, Ngoc Trong Tuong Than, Anthony Huy Dinh Le, Muhammad Sohail Halim and 1 more

Abstract read
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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jonathan RegenoldSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Hien Luong DoanSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Hashem GhorabaSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Hassan KhojastehSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Jaclyn Joyce Jaclyn HwangSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Negin YavariSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Amir AkhavanrezayatSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Ngoc Trong Tuong ThanSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Anthony Huy Dinh LeSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Muhammad Sohail HalimSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, CA, 94303, USA. ndquan@stanford.edu.ORCID 0000-0002-6024-8441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiopsys® NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG magnitude and implicit time (converted from phase) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively.

methodsTwelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys® Espion 2™ and Diopsys® NOVA™ fixed-luminance flicker testing. Diopsys® magnitude and implicit time (converted from phase) measurements were compared to Diagnosys® amplitude and implicit time measurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland-Altman plots were utilized to determine agreement between the comparison groups.

resultsAge of patients ranged from 14 to 87 years. 58% (n = 7/12) of patients were female. A significant, positive correlation (r = 0.880, P < 0.001) was observed between magnitude (Diopsys®) and amplitude (Diagnosys®) measurements. Amplitude increases by 6.69 µV for each 1 µV increase in Magnitude (p-value < 0.001). A statistically significant, strong positive correlation was observed between Diopsys® implicit time measurements (converted from phase) and Diagnosys® implicit time measurements (r = 0.814, p-value < 0.001). For each 1 ms increase in Diopsys® implicit time, Diagnosys® implicit time increases by 1.13 ms (p-value < 0.001).

conclusionsThere is a statistically significant positive correlation between light-adapted Diopsys® NOVA™ fixed-luminance flicker amplitude and Diagnosys® flicker magnitude values. Additionally, there is a statistically significant positive correlation between Diopsys® NOVA™ fixed-luminance flicker implicit time (converted from phase) and Diagnosys® flicker implicit time values. These results imply that the Diopsys® NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG measurements.

Indexed as

ElectroretinographyRetinaAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPhotic StimulationYoung AdultDiagnosys®Diopsys®Fixed luminanceFlicker electroretinographyFull-field electroretinography

Identifiers

PMID37219642

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.