Evidence map›Paper›PMID 37222855›Full record

ReviewNeuroscience bulletin2023

Advances and Applications of Brain Organoids.

Yang Li, Peng-Ming Zeng, Jian Wu, Zhen-Ge Luo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yang Li *School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Peng-Ming Zeng *School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Jian Wu *School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhen-Ge LuoSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. luozhg@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0001-5037-0542

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the "brain organoid" integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids.

Indexed as

Induced Pluripotent Stem CellsNeurodegenerative DiseasesAnimalsBrainDisease Models, AnimalHumansMiceOrganoidsBrain developmentBrain organoidHuman pluripotent stem cellNeurological disease

Identifiers

PMID37222855
PMCPMC10603019

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.