Evidence map›Paper›PMID 37223041›Full record

ArticleFrontiers in endocrinology2023

Transcriptomic changes in liver transplant recipients with non-alcoholic steatohepatitis indicate dysregulation of wound healing.

Diogo Pellegrina, Khairunnadiya Prayitno, Amirhossein Azhie, Elisa Pasini, Cristina Baciu, Sandra Fischer, Jüri Reimand, Mamatha Bhat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Diogo PellegrinaComputational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Khairunnadiya PrayitnoMulti-Organ Transplant Program, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Amirhossein AzhieMulti-Organ Transplant Program, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Elisa PasiniMulti-Organ Transplant Program, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Cristina BaciuMulti-Organ Transplant Program, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Sandra FischerDepartment of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada.
Jüri ReimandComputational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Mamatha BhatMulti-Organ Transplant Program, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
University Health Network · CAToronto General Hospital · CAUniversity of Toronto · CAOntario Institute for Cancer Research · CA

Funding

CIHR
6 · The paper itself

Abstract

Background: Non-alcoholic steatohepatitis (NASH) has become a leading indication for liver transplantation. However, it often recurs in the graft and can also arise Methods: Here, we profiled the transcriptomes of livers with PT-NASH from liver transplant recipients to identify dysregulated genes, pathways, and molecular interaction networks. Results: Transcriptomic changes in the PI3K-Akt pathway were observed in association with metabolic alterations in PT-NASH. Other significant changes in gene expression were associated with DNA replication, cell cycle, extracellular matrix organization, and wound healing. A systematic comparison with non-transplant NASH (NT-NASH) liver transcriptomes indicated an increased activation of wound healing and angiogenesis pathways in the post-transplant condition. Conclusion: Beyond altered lipid metabolism, dysregulation of wound healing and tissue repair mechanisms may contribute to the accelerated development of fibrosis associated with PT-NASH. This presents an attractive therapeutic avenue to explore for PT-NASH to optimize the benefit and survival of the graft.

Indexed as

Liver TransplantationNon-alcoholic Fatty Liver DiseaseGene Expression ProfilingHumansPhosphatidylinositol 3-KinasesTranscriptomePhosphatidylinositol 3-Kinasescomputational biology & bioinformaticsdisease pathogenesisfibrosisliver transplantationnon-alcoholic fatty liver diseasenon-alcoholic steatohepatitistranscriptomics (RNA-seq)wound healing

Identifiers

PMID37223041
PMCPMC10200958
OpenAlexW4377940318

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.