Evidence map›Paper›PMID 37223650›Full record

ArticleComprehensive psychoneuroendocrinology2023

Inflammatory and mental health sequelae of COVID-19.

Jennifer M Loftis, Evan Firsick, Kate Shirley, James L Adkins, Anh Le-Cook, Emily Sano, Rebekah Hudson, Jonathan Moorman

Open access · goldAbstract read
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. COVID-19: a multi-organ perspective.Frontiers in cellular and infection microbiology · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jennifer M LoftisResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
Evan FirsickResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
Kate ShirleyResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
James L AdkinsResearch Service, Department of Veterans Affairs, James H. Quillen Veterans Affairs Medical Center, Johnson City, TN, USA.
Anh Le-CookResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
Emily SanoResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
Rebekah HudsonResearch & Development Service, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA.
Jonathan MoormanResearch Service, Department of Veterans Affairs, James H. Quillen Veterans Affairs Medical Center, Johnson City, TN, USA.
VA Portland Health Care System · USEast Tennessee State University · USOregon Health & Science University · US

Funding

HCV and co-morbid alcohol use disorders: a translational investigation of antiviral therapy outcomes on CNS functionI01BX002061 · VA · PORTLAND VA MEDICAL CENTER · PI LOFTIS, JENNIFER M · 2014 to 2023
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COVID-19: Characterizing trained immune responses to COVID-19I01BX005428 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI MOORMAN, JONATHAN P · 2021 to 2022
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BLRD VA I01 BX002061BLRD VA I01 BX005428CSRD VA I01 CX002668
6 · The paper itself

Abstract

The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment ("brain fog"), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]. The present study sought to examine the role of inflammatory factors as predictors of neuropsychiatric symptom severity in the context of COVID-19. Adults (n = 52) who tested negative or positive for COVID-19 were asked to complete self-report questionnaires and to provide blood samples for multiplex immunoassays. Participants who tested negative for COVID-19 were assessed at baseline and at a follow-up study visit (∼4 weeks later). Individuals without COVID-19 reported significantly lower PHQ-4 scores at the follow-up visit, as compared to baseline (

Indexed as

AnxietyChemokineCognitionCytokineDepressionLong COVID

Identifiers

PMID37223650
PMCPMC10191701
OpenAlexW4377104175

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.