Evidence map›Paper›PMID 37223966›Full record

ArticleMolecular biology of the cell2023

Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in

Hsiao Yu Fang, Rameen Forghani, Akanni Clarke, Philip G McQueen, Aravind Chandrasekaran, Kate M O'Neill, Wolfgang Losert, Garegin A Papoian, Edward Giniger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hsiao Yu FangNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Rameen ForghaniNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Akanni ClarkeNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Philip G McQueenNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Aravind ChandrasekaranNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Kate M O'NeillNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Wolfgang LosertInstitute for Physical Sciences and Department of Physics, University of Maryland, College Park, MD 20752.
Garegin A PapoianDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20752.
Edward GinigerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
National Institutes of Health · USUniversity of Maryland, College Park · US

Funding

Mechanisms of axon guidance during developmentZIANS003013 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GINIGER, EDWARD · 2009 to 2025
$17.2M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Mechanisms of axon guidance during developmentZ01NS003013 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GINIGER, EDWARD · 2005 to 2008
$2.0M
Intramural NIH HHS Z01 NS003013NIH HHS P40 OD018537
6 · The paper itself

Abstract

Ena/VASP proteins are processive actin polymerases that are required throughout animal phylogeny for many morphogenetic processes, including axon growth and guidance. Here we use in vivo live imaging of morphology and actin distribution to determine the role of Ena in promoting the growth of the TSM1 axon of the

Indexed as

ActinsGrowth ConesAnimalsAxonsDNA-Binding ProteinsDrosophilaProto-Oncogene Proteins c-ablActinsDNA-Binding ProteinsENA-VASP proteinsProto-Oncogene Proteins c-abl

Identifiers

PMID37223966
PMCPMC10398877
OpenAlexW4377940173

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.