Evidence map›Paper›PMID 37224641›Full record

ReviewCurrent opinion in structural biology2023

Reprogramming of three-dimensional chromatin organization in the early embryo.

Alexandra Theis, Melissa M Harrison

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in structural biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Transcription regulation by biomolecular condensates.Nature reviews. Molecular cell biology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. The emerging H3K9me3 chromatin landscape during zebrafish embryogenesis.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandra TheisDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: atheis@wisc.edu.
Melissa M HarrisonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: mharrison3@wisc.edu.
University of Wisconsin System · US

Funding

Genomic reprogramming in the early embryoR35GM136298 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Melissa Harrison · 2020 to 2026
$2.8M
Shared mechanisms regulate transcription-factor activity to control cell fate in neural stem cells and the embryoR01NS111647 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HARRISON, MELISSA, LEE, CHENG-YU · 2019 to 2023
$1.7M
NIGMS NIH HHS R35 GM136298NINDS NIH HHS R01 NS111647
6 · The paper itself

Abstract

Chromatin organization within the three-dimensional (3D) nuclear space is important for proper gene expression and developmental programming. This organization is established during the dramatic reprogramming that occurs in early embryonic development. Thus, the early embryo is an ideal model for examining the formation and dynamics of 3D chromatin structure. Advances in high-resolution microscopy and single-nucleus genomic analyses have provided fundamental insights into the mechanisms driving genome organization in the early embryo. Here, we highlight recent findings describing the dynamics and driving mechanisms for establishing 3D chromatin organization and discuss the role such organization has on gene regulation in early embryonic development.

Indexed as

Cell NucleusChromatinEmbryo, MammalianEmbryonic DevelopmentChromatin

Identifiers

PMID37224641
PMCPMC10524315
OpenAlexW4377261850

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.