Evidence map›Paper›PMID 37227818›Full record

ArticleCell reports2023

Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle.

Maggie S Matern, Robert Durruthy-Durruthy, Onur Birol, Spyros Darmanis, Mirko Scheibinger, Andrew K Groves, Stefan Heller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Maggie S MaternDepartment of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Robert Durruthy-DurruthyDepartment of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Onur BirolDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Spyros DarmanisDepartments of Bioengineering and Applied Physics and Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Mirko ScheibingerDepartment of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Andrew K GrovesDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Stefan HellerDepartment of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: hellers@stanford.edu.
Stanford Medicine · USBaylor College of Medicine · USGeorgia Institute of Technology · USHoward Hughes Medical Institute · US

Funding

Genetic Regulation of Cochlear DevelopmentR01DC017689 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI GROVES, ANDREW K, HELLER, STEFAN · 2019 to 2023
$3.1M
The gEAR portal - Advancing Data Sharing, Analysis and Discovery for Hearing and Balance ResearchR01DC019370 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MAHURKAR, ANUP · 2021 to 2022
$1.5M
Clinician-scientist training program in otolaryngologyT32DC015209 · NIDCD · STANFORD UNIVERSITY · PI CHENG, ALAN GI-LUN · 2016 to 2021
$807k
Otic GuidanceR21DC019910 · NIDCD · STANFORD UNIVERSITY · PI HELLER, STEFAN · 2022 to 2023
$433k
NIDCD NIH HHS R01 DC017689NIDCD NIH HHS R01 DC019370NIDCD NIH HHS R21 DC019910NIDCD NIH HHS T32 DC015209
6 · The paper itself

Abstract

An abundance of research has recently highlighted the susceptibility of cochleovestibular ganglion (CVG) neurons to noise damage and aging in the adult cochlea, resulting in hearing deficits. Furthering our understanding of the transcriptional cascades that contribute to CVG development may provide insight into how these cells can be regenerated to treat inner ear dysfunction. Here we perform a high-depth single-cell RNA sequencing analysis of the E10.5 otic vesicle and its surrounding tissues, including CVG precursor neuroblasts and emerging CVG neurons. Clustering and trajectory analysis of otic-lineage cells reveals otic markers and the changes in gene expression that occur from neuroblast delamination toward the development of the CVG. This dataset provides a valuable resource for further identifying the mechanisms associated with CVG development from neurosensory competent cells within the otic vesicle.

Indexed as

CochleaNeural Stem CellsAnimalsGene Expression Regulation, DevelopmentalMiceNeuronscochleacochleovestibular ganglionCP: Neuroscienceneurogenesisotic neuroblastsotic placodeotic vesiclescRNA-seqvestibular

Identifiers

PMID37227818
PMCPMC10592509
OpenAlexW4377691182

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.