Evidence map›Paper›PMID 37228375›Full record

ArticleFrontiers in microbiology2023

Maternal HIV infection drives altered placental

Nadege Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Ryan P McNamara, Sarah M Fortune, Kees L M C Franken, Tom H M Ottenhoff, Bryan Bryson, Joseph Ngonzi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Impact ofFrontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Nadege NzizaRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Wonyeong JungRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Maanasa MenduDepartment of Molecular and Cellular Biology, Harvard University, Boston, MA, United States.
Tina ChenRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Ryan P McNamaraRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Sarah M FortuneRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Kees L M C FrankenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Bryan BrysonRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Joseph NgonziDepartment of Obstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, Uganda.
Lisa M BebellDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States.
Galit AlterRagon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Ragon Institute of MGH, MIT and Harvard · USLeiden University Medical Center · NLCenter for Global Health · USHarvard University · USMassachusetts Institute of Technology · USMbarara University of Science and Technology · UG

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
Demystifying the antiviral activity of the IgG3+ antibody responseR37AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2015 to 2022
$5.8M
Demystifying the antiviral activity of the IgG3+ antibody responseR01AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JUELG, BORIS DOMINIK · 2009 to 2024
$4.1M
HIV Infection, Placental Inflammation, and Early Childhood Outcomes in HIV-exposed, Uninfected Infants in UgandaK23AI138856 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BEBELL, LISA M · 2019 to 2023
$1.1M
Mapping and dissecting the role of antibodies in Mtb controlR56AI155149 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2020 to 2020
$815k
NCATS NIH HHS KL2 TR002542NIAID NIH HHS K23 AI138856NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI080289NIAID NIH HHS R56 AI155149
6 · The paper itself

Abstract

Introduction: Placental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at higher risk of developing severe infections, including active tuberculosis (TB). Given our emerging appreciation for the potential role of antibodies in the control of Methods: Antigen-specific antibody systems serology was performed to comprehensively characterize the Results: Significant differences were noted in overall antibody profiles in HIV positive and negative maternal plasma, resulting in heterogeneous transfer of Conclusions: These results highlight the importance of maternal HIV status on antibody transfer, providing clues related to alterations in transferred maternal immunity that may render HEU infants more vulnerable to TB than their HIV-unexposed peers.

Indexed as

antibodyHIVneonateplacental transfertuberculosis

Identifiers

PMID37228375
PMCPMC10203169
OpenAlexW4378348488

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.