Evidence map›Paper›PMID 37232739›Full record

ReviewCurrent issues in molecular biology2023

Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update.

Tea Omanovic Kolaric, Lucija Kuna, Marina Covic, Hrvoje Roguljic, Anita Matic, Renata Sikora, Marija Hefer, Ana Petrovic, Vjera Mihaljevic, Robert Smolic and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Tea Omanovic KolaricDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Lucija KunaDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.ORCID 0000-0002-0079-2349
Marina CovicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.ORCID 0000-0003-1206-782X
Hrvoje RoguljicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Anita MaticDepartment of Pharmacology, Faculty of Medicine, 31000 Osijek, Croatia.ORCID 0000-0002-3374-8512
Renata SikoraDepartment of Dental Medicine, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.ORCID 0000-0001-8594-549X
Marija HeferDepartment of Physics, Biophysics, and Chemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.ORCID 0009-0003-9996-1652
Ana PetrovicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Vjera MihaljevicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Robert SmolicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Ines Bilic-CurcicDepartment of Pharmacology, Faculty of Medicine, 31000 Osijek, Croatia.ORCID 0000-0002-8861-5987
Aleksandar VcevDepartment of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.
Martina SmolicDepartment of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, 31000 Osijek, Croatia.ORCID 0000-0002-6867-826X
University of Osijek · HR

Funding

Croatian Ministry of Science, Education and Sports dedicated to multi-year institutional funding of scientific activity at the Josip Juraj Strossmayer University of Osijek, Osijek, Croatia IP7-FDMZ-2022
6 · The paper itself

Abstract

Liver fibrosis represents one of the greatest challenges in medicine. The fact that it develops with the progression of numerous diseases with high prevalence (NAFLD, viral hepatitis, etc.) makes liver fibrosis an even greater global health problem. Accordingly, it has received much attention from numerous researchers who have developed various in vitro and in vivo models to better understand the mechanisms underlying fibrosis development. All these efforts led to the discovery of numerous agents with antifibrotic properties, with hepatic stellate cells and the extracellular matrix at the center of these pharmacotherapeutic strategies. This review focuses on the current data on numerous in vivo and in vitro models of liver fibrosis and on various pharmacotherapeutic targets in the treatment of liver fibrosis.

Indexed as

hepatic stellate cellsliver fibrosisNAFLD

Identifiers

PMID37232739
PMCPMC10216970
OpenAlexW4378347944

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.