Evidence map›Paper›PMID 37235778›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study.

Pratik Pokharel, Jamie W Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B Yeap, Emma Connolly, Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Pratik PokharelNutrition and Biomarkers, The Danish Cancer Society Research Center, Copenhagen 2100, Denmark.ORCID 0000-0001-5815-5927
Jamie W BellingeMedical School, University of Western Australia, Perth, Western Australia 6009, Australia.
Frederik DalgaardDepartment of Medicine, Nykøbing Falster Sygehus, Nykøbing 4800, Denmark.
Kevin MurraySchool of Population and Global Health, University of Western Australia, Perth, Western Australia 6009, Australia.ORCID 0000-0002-8856-6046
Marc SimNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.ORCID 0000-0001-5166-0605
Bu B YeapMedical School, University of Western Australia, Perth, Western Australia 6009, Australia.
Emma ConnollyNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.
Lauren C BlekkenhorstNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.
Catherine P BondonnoNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.
Joshua R LewisNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.
Gunnar GislasonDepartment of Cardiology, Herlev & Gentofte University Hospital, Copenhagen 2730, Denmark.
Anne TjønnelandDiet, Cancer and Health, The Danish Cancer Society Research Center, Copenhagen 2100, Denmark.ORCID 0000-0003-4385-2097
Kim OvervadDepartment of Public Health, Aarhus University, Aarhus 8000, Denmark.ORCID 0000-0001-6429-7921
Jonathan M HodgsonNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia 6000, Australia.
Carl SchultzMedical School, University of Western Australia, Perth, Western Australia 6009, Australia.ORCID 0000-0002-0847-4361
Nicola P BondonnoNutrition and Biomarkers, The Danish Cancer Society Research Center, Copenhagen 2100, Denmark.ORCID 0000-0001-5905-444X
Edith Cowan University · AUThe University of Western Australia · AUUniversity of Copenhagen · DKAarhus University · DKGentofte Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextObservational studies have reported lower risks of type 2 diabetes with higher vitamin K1 intake, but these studies overlook effect modification due to known diabetes risk factors.

objectiveTo identify subgroups that might benefit from vitamin K1 intake, we examined associations between vitamin K1 intake and incident diabetes overall and in subpopulations at risk of diabetes.

methodsParticipants from the prospective cohort, the Danish Diet, Cancer, and Health Study, with no history of diabetes were followed up for diabetes incidence. The association between intake of vitamin K1, estimated from a food frequency questionnaire completed at baseline, and incident diabetes was determined using multivariable-adjusted Cox proportional-hazards models.

resultsIn 54 787 Danish residents with a median (interquartile range) age of 56 (52-60) years at baseline, 6700 individuals were diagnosed with diabetes during 20.8 (17.3-21.6) years of follow-up. Vitamin K1 intake was inversely and linearly associated with incident diabetes (P < .0001). Compared to participants with the lowest vitamin K1 intake (median:57 µg/d), participants with the highest intakes (median:191 µg/d) had a 31% lower risk of diabetes (HR; 95% CI, 0.69; 0.64-0.74) after multivariable adjustments. The inverse association between vitamin K1 intake and incident diabetes was present in all subgroups (namely, men and women, ever and never smokers, low and high physical activity groups, and in participants who were normal to overweight and obese), with differences in absolute risk between subgroups.

conclusionHigher intake of foods rich in vitamin K1 was associated with a lower risk of diabetes. If the associations observed are causal, our results indicate that more cases of diabetes would be prevented in subgroups at higher risk (men, smokers, participants with obesity, and those with low physical activity).

Indexed as

Diabetes Mellitus, Type 2NeoplasmsDenmarkDietFemaleHumansMaleMiddle AgedObesityProspective StudiesRisk FactorsVitamin K 1Vitamin K 2Vitamin K 1Vitamin K 2dietnon–insulin-dependent diabetesnutrition epidemiologyobesityphylloquinonetype 2 diabetes mellitus

Identifiers

PMID37235778
PMCPMC10583989
OpenAlexW4378469806

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.