Evidence map›Paper›PMID 37236435›Full record

ArticleEuropean journal of pharmacology2023

Focal adhesion kinase activation is involved in contractile stimulation-induced detrusor muscle contraction in mice.

Shaimaa Maher, Mekki Bayachou, Pingfu Fu, Adonis Hijaz, Guiming Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Shaimaa MaherDepartment of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA; Department of Chemistry, Cleveland State University, Cleveland, OH, USA.
Mekki BayachouDepartment of Chemistry, Cleveland State University, Cleveland, OH, USA; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Pingfu FuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Adonis HijazDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Guiming LiuDepartment of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: guiming.liu@case.edu.
Cleveland State University · USCase Western Reserve University · USMetroHealth Medical Center · USUniversity Hospitals of Cleveland · US

Funding

Phenotrypes and Mechanisms of Urinary Incontinence in Obesity/pre-Type 2 DiabetesR01DK110567 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DANESHGARI, FIROUZ, LIU, GUIMING · 2016 to 2020
$1.8M
Selenium-based electrocatalytic sensors for sensitive peroxynitrite detection in biological media: a bottom-up approach for functional interface designR15GM140405 · NIGMS · CLEVELAND STATE UNIVERSITY · PI BAYACHOU, MEKKI · 2021 to 2023
$547k
NIDDK NIH HHS R01 DK110567NIGMS NIH HHS R15 GM140405
6 · The paper itself

Abstract

Recent studies suggested smooth muscle contraction may involve mechanisms besides the myosin regulatory light chain (MLC) phosphorylation-induced actomyosin crossbridge cycling. This study aims to determine if focal adhesion kinase (FAK) activation is involved in mouse detrusor muscle contraction. The mouse detrusor muscle strips were preincubated with PF-573228 (2 μM), latrunculin B (1 μM), or the same volume of vehicle (DMSO) for 30 min. The contractile responses to KCl (90 mM), electrical field stimulation (EFS, 2-32 Hz), or carbachol (CCh, 10

Indexed as

Dimethyl SulfoxideMuscle ContractionAnimalsBridged Bicyclo Compounds, HeterocyclicCarbacholFocal Adhesion Protein-Tyrosine KinasesMiceQuinolonesSulfonesThiazolidines6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-oneBridged Bicyclo Compounds, HeterocyclicCarbacholDimethyl SulfoxideFocal Adhesion Protein-Tyrosine Kinaseslatrunculin BQuinolonesSulfonesThiazolidinesActin polymerizationBladderContractilityDetrusor muscleFAK

Identifiers

PMID37236435
PMCPMC10330804
OpenAlexW4377968590

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.