Evidence mapPaperPMID 37238742Full record

ReviewBiomolecules2023

Organoids: Construction and Application in Gastric Cancer.

Chengdong Huo, Xiaoxia Zhang, Yanmei Gu, Daijun Wang, Shining Zhang, Tao Liu, Yumin Li, Wenting He

Abstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Identifying early warning signals of cancer formation.Quantitative biology (Beijing, China) · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Organoids in cancer therapies: a comprehensive review.Frontiers in bioengineering and biotechnology · 2025
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengdong HuoDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.ORCID 0000-0003-1843-4803
Xiaoxia ZhangDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Yanmei GuDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Daijun WangDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Shining ZhangKey Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China.
Tao LiuDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Yumin LiDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Wenting HeDepartment of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric organoids are biological models constructed in vitro using stem cell culture and 3D cell culture techniques, which are the latest research hotspots. The proliferation of stem cells in vitro is the key to gastric organoid models, making the cell subsets within the models more similar to in vivo tissues. Meanwhile, the 3D culture technology also provides a more suitable microenvironment for the cells. Therefore, the gastric organoid models can largely restore the growth condition of cells in terms of morphology and function in vivo. As the most classic organoid models, patient-derived organoids use the patient's own tissues for in vitro culture. This kind of model is responsive to the 'disease information' of a specific patient and has great effect on evaluating the strategies of individualized treatment. Herein, we review the current literature on the establishment of organoid cultures, and also explore organoid translational applications.

Indexed as

Stomach NeoplasmsCell Culture TechniquesHumansModels, BiologicalOrganoidsStem CellsTumor Microenvironment3D cell cultureorganoidpatient-derived organoids (PDO)stem celltumor organoid

Identifiers

PMID37238742
PMCPMC10216466

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.