Evidence map›Paper›PMID 37239000›Full record

ArticleBiomedicines2023

Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell Subsets from Systemic Sclerosis Patients.

Paula Laranjeira, Francisco Dos Santos, Maria João Salvador, Irina N Simões, Carla M P Cardoso, Bárbara M Silva, Helena Henriques-Antunes, Luísa Corte-Real, Sofia Couceiro, Filipa Monteiro and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Paula LaranjeiraFlow Cytometry Unit, Department of Clinical Pathology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.ORCID 0000-0002-1136-6118
Francisco Dos SantosStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.ORCID 0000-0002-2046-2742
Maria João SalvadorRheumatology Department, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
Irina N SimõesStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.ORCID 0000-0003-1861-8485
Carla M P CardosoStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.ORCID 0000-0002-0985-7487
Bárbara M SilvaAlgarve Biomedical Center (ABC), Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-3314-7936
Helena Henriques-AntunesStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.
Luísa Corte-RealStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.
Sofia CouceiroStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.ORCID 0009-0005-2926-6632
Filipa MonteiroStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.
Carolina SantosStemlab S.A., Famicord Group, 3060-197 Cantanhede, Portugal.
Tânia SantiagoRheumatology Department, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.ORCID 0000-0002-1562-4022
José A P da SilvaCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Artur PaivaFlow Cytometry Unit, Department of Clinical Pathology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.ORCID 0000-0002-6562-5859
Hospitais da Universidade de Coimbra · PTAlgarve Biomedical Center · PT

Funding

Portugal 2020, Programa Operacional Competitividade e Internacionalização & European Regional Development Fund POCI-01-0247-FEDER-038313Portugal 2020, Programa Operacional Competitividade e Internacionalização & European Regional Development Fund POCI-01-02B7-FEDER-048816
6 · The paper itself

Abstract

Systemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononuclear cells from healthy individuals (HC,

Indexed as

cellular therapyimmunomodulatory potentialmesenchymal stem cellsmesenchymal stromal cells (MSCs)systemic sclerosisT cell activationT cell polarizationT cellsTh17Treg

Identifiers

PMID37239000
PMCPMC10215673
OpenAlexW4367628110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.