Evidence map›Paper›PMID 37239465›Full record

ArticleGenes2023

ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity.

Matthieu Halfon, Li Zhang, Driss Ehirchiou, Vishnuprabu Durairaj Pandian, Suzan Dahdal, Uyen Huynh-Do, Andreas Pasch, Camillo Ribi, Nathalie Busso

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. A CCL5Cell & bioscience · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Matthieu HalfonTransplantation Center, Lausanne University Hospital, 1010 Lausanne, Switzerland.
Li ZhangDepartment of Physiology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Driss EhirchiouService of Rheumatology, Department of Musculoskeletal Medicine, Lausanne University Hospital, University of Lausanne, 1010 Lausanne, Switzerland.ORCID 0009-0004-2275-9859
Vishnuprabu Durairaj PandianDepartment of Physiology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Suzan DahdalDivision of Nephrology and Hypertension, University Hospital Bern Inselspital, 3010 Bern, Switzerland.
Uyen Huynh-DoDivision of Nephrology and Hypertension, University Hospital Bern Inselspital, 3010 Bern, Switzerland.
Andreas PaschDepartment of Physiology and Pathophysiology, Linz University, 4040 Linz, Austria.
Camillo RibiSwiss Systemic Lupus Erythematosus Cohort Study.ORCID 0000-0002-0446-9741
Nathalie BussoService of Rheumatology, Department of Musculoskeletal Medicine, Lausanne University Hospital, University of Lausanne, 1010 Lausanne, Switzerland.
University of Lausanne · CHUniversity Hospital of Bern · CHUniversity of Maryland, Baltimore · USSwiss HIV Cohort Study · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCD11B/ITGAM (Integrin Subunit α M) mediates the adhesion of monocytes, macrophages, and granulocytes and promotes the phagocytosis of complement-coated particles. Variants of the ITGAM gene are candidates for genetic susceptibility to systemic lupus erythematosus (SLE). SNP rs1143679 (R77H) of CD11B particularly increases the risk of developing SLE. Deficiency of CD11B is linked to premature extra-osseous calcification, as seen in the cartilage of animals with osteoarthritis. Serum calcification propensity measured by the T50 test is a surrogate marker for systemic calcification and reflects increased cardiovascular (CV) risk. We aimed to assess whether the CD11B R77H gene variant is associated with a higher serum calcification propensity (i.e., a lower T50 value) in SLE patients compared to the wild-type allele (WT).

methodsCross-sectional study incorporating adults with SLE genotyped for the CD11B variant R77H and assessed for serum calcification propensity with the T50 method. Participants were included in a multicenter trans-disciplinary cohort and fulfilled the 1997 revised American College of Rheumatology (ACR) criteria for SLE. We used descriptive statistics for comparing baseline characteristics and sequential T50 measurements in subjects with the R77H variant vs. WT CD11B.

resultsOf the 167 patients, 108 (65%) were G/G (WT), 53 (32%) were G/A heterozygous, and 6 (3%) were A/A homozygous for the R77H variant. A/A patients cumulated more ACR criteria upon inclusion (7 ± 2 vs. 5 ± 1 in G/G and G/A;

conclusionsSLE patients with homozygosity for the R77H variant and repeated T50 assessment displayed an increased serum calcification propensity (i.e., a lower T50) and lower C3 levels compared to heterozygous and WT CD11B, without differing with respect to global disease activity and kidney involvement. This suggests an increased CV risk in SLE patients homozygous for the R77H variant of CD11B.

Indexed as

CalcinosisCD11b AntigenLupus Erythematosus, SystemicCross-Sectional StudiesGenetic Predisposition to DiseaseGenotypeHumansMacrophagesCD11b AntigenITGAM protein, humancalcification propensityCD11BcomplementITGAMlupus

Identifiers

PMID37239465
PMCPMC10218643
OpenAlexW4377139564

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.