Evidence map›Paper›PMID 37239742›Full record

ArticleHealthcare (Basel, Switzerland)2023

Herbal Medicine Yukgunja-Tang for Functional Dyspepsia: A Protocol for a Randomized, Controlled, Multicenter Clinical Trial.

Boram Lee, Na-Yeon Ha, Hyo-Ju Park, Ae-Ran Kim, O-Jin Kwon, Jung-Hyo Cho, Seon Mi Shin, Jinsung Kim, Changsop Yang

Open access · goldAbstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Boram LeeKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.ORCID 0000-0003-1679-0644
Na-Yeon HaDivision of Digestive Diseases, Department of Internal Korean Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.ORCID 0000-0001-6611-0147
Hyo-Ju ParkClinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Ae-Ran KimClinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
O-Jin KwonKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.ORCID 0000-0002-7349-4596
Jung-Hyo ChoDepartment of Internal Medicine, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon 35235, Republic of Korea.
Seon Mi ShinDepartment of Internal Medicine, College of Korean Medicine, Semyung University, Jecheon-si 27136, Republic of Korea.ORCID 0000-0003-1660-2973
Jinsung KimDepartment of Gastroenterology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.ORCID 0000-0002-2164-357X
Changsop YangKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.ORCID 0000-0003-1277-3329
Korea Institute of Oriental Medicine · KRKyung Hee University Medical Center · KRDaejeon University · KRSemyung University · KR

Funding

Korea Institute of Oriental Medicine KSN2022210
6 · The paper itself

Abstract

The herbal medicine Yukgunja-tang has been widely used for the treatment of functional dyspepsia (FD) in the clinical setting of East Asian traditional medicine. This paper presents a protocol for a randomized, assessor-blind, controlled, multicenter, three-arm parallel clinical trial comparing the effectiveness, safety, and cost-effectiveness of Yukgunja-tang with Pyeongwi-san and usual care. A total of 140 participants with Rome IV-diagnosed FD will be randomly assigned to either the Yukgunja-tang (n = 56), Pyeongwi-san (n = 56), or usual care (n = 28) groups. All participants will be educated on dietary guidelines for FD patients. Participants in the Yukgunja-tang and Pyeongwi-san groups will take investigational products for 6 weeks. All participants will be assessed for clinical parameters at weeks 0, 3, 6, 9, and 24. The primary outcome will be measured on the total dyspepsia symptom scale, and the secondary outcome will include the single dyspepsia symptom scale, overall treatment effect, the visual analog scale for dyspepsia, FD-related quality of life, hospital anxiety and depression scale, EuroQol-5 dimension, pattern identification, and serum levels of acyl-ghrelin and deacyl-ghrelin. Adverse events and laboratory tests will be monitored for safety assessment. The results will provide evidence of the effectiveness, safety, and cost-effectiveness of Yukgunja-tang in the treatment of FD.

Indexed as

functional dyspepsiaherbal medicineLiujunzi-tangrandomized controlled trialRikkunshitoYukgunja-tang

Identifiers

PMID37239742
PMCPMC10217900
OpenAlexW4377107956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.