ReviewInternational journal of molecular sciences2023
Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Functional MRI evidence of brain alterations in premenstrual dysphoric disorder: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Rs-fMRI reveals that taVNS improves cognitive and emotional function in mild cognitive impairment by reconfiguration of "sensory relay-salience-default" cross-network effective connectivity: a randomized, double-blind, sham-controlled trial.Frontiers in neurology · 2026Trial
- Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation.Scientific reports · 2024Trial
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Investigating Bidirectional Causal Relationships Between Imaging-Derived Brain Phenotypes and Sedative-Hypnotic Use Disorder: A Mendelian Randomization Study.Addiction biology · 2026Article
- Altered functional connectivity of emotional circuits and default mode network in postpartum women: a resting-state functional magnetic resonance imaging study.BMC psychology · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments.bioRxiv : the preprint server for biology · 2025Article
- Brain Connectivity of the Cingulate Cortex in Alcohol Use Disorder: Exploring Its Association With Mindfulness.Addiction biology · 2025Article
- Neurobiological Mechanisms of Action of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Substance Use Disorders (SUDs)-A Review.Journal of clinical medicine · 2025Review
- Multidimensional components of impulsivity during early adolescence: Relationships with brain networks and future substance-use in the Adolescent Brian and Cognitive Development (ABCD) study.bioRxiv : the preprint server for biology · 2025Article
- Insula under the influence: Alcohol-induced changes in resting state functional connectivity.Alcohol, clinical & experimental research · 2025Article
- Functional brain connectivity of the salience network in alcohol use and anxiety disorders.Journal of affective disorders · 2025Article
- Article
- Effects of alcohol and cannabis co-use on salience network resting state functional connectivity in individuals who drink alcohol heavily.Drug and alcohol dependence · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- Context-dependent Impulsivity in Substance Use Disorder: A Neuroscience-informed Framework.Current addiction reports · 2025Article
- Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder.Journal of behavioral addictions · 2024Article
- Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes.Current therapeutic research, clinical and experimental · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Human neuroimaging has demonstrated the existence of large-scale functional networks in the cerebral cortex consisting of topographically distant brain regions with functionally correlated activity. The salience network (SN), which is involved in detecting salient stimuli and mediating inter-network communication, is a crucial functional network that is disrupted in addiction. Individuals with addiction display dysfunctional structural and functional connectivity of the SN. Furthermore, while there is a growing body of evidence regarding the SN, addiction, and the relationship between the two, there are still many unknowns, and there are fundamental limitations to human neuroimaging studies. At the same time, advances in molecular and systems neuroscience techniques allow researchers to manipulate neural circuits in nonhuman animals with increasing precision. Here, we describe attempts to translate human functional networks to nonhuman animals to uncover circuit-level mechanisms. To do this, we review the structural and functional connections of the salience network and its homology across species. We then describe the existing literature in which circuit-specific perturbation of the SN sheds light on how functional cortical networks operate, both within and outside the context of addiction. Finally, we highlight key outstanding opportunities for mechanistic studies of the SN.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.