Evidence map›Paper›PMID 37241920›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors.

Dolores G Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C Cruz-López, Fabiola E Jiménez-Montejo, Víctor E López Y López, Carlos H Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dolores G Aguila-MuñozCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.
Gabriel Vázquez-LiraCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.
Erika Sarmiento-TlaleCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.
María C Cruz-LópezCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.ORCID 0000-0001-5815-0587
Fabiola E Jiménez-MontejoCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.ORCID 0000-0002-0776-1705
Víctor E López Y LópezCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.ORCID 0000-0002-1885-2901
Carlos H EscalanteDepartamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala S/N, Mexico City 11340, Mexico.ORCID 0000-0002-4625-6883
Dulce Andrade-PavónDepartamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu S/N, Mexico City 11340, Mexico.ORCID 0000-0001-9858-4806
Omar Gómez-GarcíaDepartamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala S/N, Mexico City 11340, Mexico.
Joaquín TamarizDepartamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala S/N, Mexico City 11340, Mexico.
Aarón Mendieta-MoctezumaCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, Carretera Estatal Santa Inés Tecuexcomax-Tepetitla, Km 1.5, Tepetitla de Lardizábal, Tlaxcala 90700, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase. We have synthesized novel alkoxy-substituted xanthones and imidazole-substituted xanthones and have evaluated them for their in silico and in vitro α-glucosidase and α-amylase inhibition activity. Compounds

Indexed as

Glycoside Hydrolase InhibitorsXanthonesAlcoholsalpha-Amylasesalpha-GlucosidasesHypoglycemic AgentsImidazolesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAlcoholsalkoxyl radicalalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsImidazolesXanthonesalkoxy-substituted xanthonesdiabetes mellitusimidazole-substituted xanthonesα-amylaseα-glucosidase

Identifiers

PMID37241920
PMCPMC10222686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.