Evidence map›Paper›PMID 37241973›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine-1,5-Benzodiazepine Hybrids.

Kirill P Cheremnykh, Arkadiy O Bryzgalov, Dmitry S Baev, Sergey A Borisov, Yulia S Sotnikova, Victor A Savelyev, Tatyana G Tolstikova, Shamansur S Sagdullaev, Elvira E Shults

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kirill P CheremnykhN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Arkadiy O BryzgalovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Dmitry S BaevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-1795-9256
Sergey A BorisovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-6415-5840
Yulia S SotnikovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Victor A SavelyevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Tatyana G TolstikovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Shamansur S SagdullaevS.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
Elvira E ShultsN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-0761-9696
Novosibirsk Institute of Organic Chemistry · RUYunusov Institute of the Chemistry of Plant Substances · UZ

Funding

Russian Science Foundation 23-73-00077
6 · The paper itself

Abstract

Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have long interested scientists due to their medicinal uses and infamous toxicity which has limited the clinical application of the native compound. Alkaloid lappaconitine extracted from various

Indexed as

AconitineAnalgesics, Non-NarcoticAnti-Arrhythmia AgentsBenzodiazepinesVoltage-Gated Sodium Channel BlockersAnimalsMaleMiceMice, Inbred StrainsModels, MolecularMolecular Docking SimulationNAV1.5 Voltage-Gated Sodium ChannelProtein BindingRatsRats, WistarAconitineAnalgesics, Non-NarcoticAnti-Arrhythmia AgentsBenzodiazepineslappaconitineNAV1.5 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel Blockers1,5-benzodiazepinesalkynyl ketonesanalgesic activityantiarrhythmic activitycyclocondensationditerpenoid alkaloidslappaconitineSonogashira coupling

Identifiers

PMID37241973
PMCPMC10223824
OpenAlexW4377240134

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.