Evidence map›Paper›PMID 37242709›Full record

ArticlePharmaceutics2023

Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation.

Martina Pedrini, Angelo Iannielli, Lorenzo Meneghelli, Daniele Passarella, Vania Broccoli, Pierfausto Seneci

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Proteolytic therapeutic modalities for amyloidoses: Insights into immunotherapy, PROTAC, and photo-oxygenation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Martina PedriniChemistry Department, Milan University, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0003-4332-7241
Angelo IannielliNeuroscience Institute, Consiglio Nazionale delle Ricerche (CNR), Via Olgettina 58, 20132 Milan, Italy.ORCID 0000-0003-0894-5263
Lorenzo MeneghelliChemistry Department, Milan University, Via Golgi 19, 20133 Milan, Italy.
Daniele PassarellaChemistry Department, Milan University, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0001-6180-9581
Vania BroccoliNeuroscience Institute, Consiglio Nazionale delle Ricerche (CNR), Via Olgettina 58, 20132 Milan, Italy.ORCID 0000-0003-4050-0926
Pierfausto SeneciChemistry Department, Milan University, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0001-9709-7344
University of Milan · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for disease-modifying agents targeted against Parkinson's disease led us to rationally design a small array of six Anle138b-centered PROTACs,

Indexed as

4xSNCA DANsAnle138bmedicinal chemistryneurodegenerationoncologyParkinson’s diseasePROTACsprotein degradationThioflavin Tubiquitin proteasome systemα-Synuclein

Identifiers

PMID37242709
PMCPMC10221781
OpenAlexW4376280128

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.