Evidence map›Paper›PMID 37242945›Full record

ArticlePolymers2023

Composite Hydrogels Based on Cross-Linked Chitosan and Low Molecular Weight Hyaluronic Acid for Tissue Engineering.

Maria Drozdova, Marina Vodyakova, Tatiana Tolstova, Marina Chernogortseva, Nikita Sazhnev, Tatiana Demina, Nadezhda Aksenova, Peter Timashev, Nataliya Kildeeva, Elena Markvicheva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of hyaluronic acid on skin at the cellular level: a systematic review.Revista da Associacao Medica Brasileira (1992) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maria DrozdovaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0002-7858-0864
Marina VodyakovaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.
Tatiana TolstovaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0001-9053-6551
Marina ChernogortsevaDepartment of Chemistry and Technology of Polymer Materials and Nanocomposites, The Kosygin Russian State University, 1 Malaya Kaluzhskaya Str., 119071 Moscow, Russia.
Nikita SazhnevDepartment of Chemistry and Technology of Polymer Materials and Nanocomposites, The Kosygin Russian State University, 1 Malaya Kaluzhskaya Str., 119071 Moscow, Russia.
Tatiana DeminaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, Russia.ORCID 0000-0003-0271-2231
Nadezhda AksenovaSemenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 4 Kosygina Str., 119991 Moscow, Russia.ORCID 0000-0003-0527-8899
Peter TimashevWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov First Moscow State Medical University, 8-2 Trubetskaya Str., 119991 Moscow, Russia.ORCID 0000-0001-7773-2435
Nataliya KildeevaDepartment of Chemistry and Technology of Polymer Materials and Nanocomposites, The Kosygin Russian State University, 1 Malaya Kaluzhskaya Str., 119071 Moscow, Russia.ORCID 0000-0002-7951-4703
Elena MarkvichevaShemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.
Institute of Bioorganic Chemistry · RUSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation FFSM-2021-0006Russian Science Foundation grant 22-13-00261
6 · The paper itself

Abstract

The objectives of the study were as follows: (1) to develop two methods for the preparation of macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels based on covalently cross-linked Ch and low molecular weight (Mw) HA (5 and 30 kDa); (2) to investigate some properties (swelling and in vitro degradation) and structures of the hydrogels; (3) to evaluate the hydrogels in vitro as potential biodegradable matrices for tissue engineering. Chitosan was cross-linked with either genipin (Gen) or glutaraldehyde (GA). Method 1 allowed the distribution of HA macromolecules within the hydrogel (bulk modification). In Method 2, hyaluronic acid formed a polyelectrolyte complex with Ch over the hydrogel surface (surface modification). By varying compositions of the Ch/HA hydrogels, highly porous interconnected structures (with mean pore sizes of 50-450 μm) were fabricated and studied using confocal laser scanning microscopy (CLSM). Mouse fibroblasts (L929) were cultured in the hydrogels for 7 days. Cell growth and proliferation within the hydrogel samples were studied via MTT-assay. The entrapment of low molecular weight HA was found to result in an enhancement of cell growth in the Ch/HA hydrogels compared to that in the Ch matrices. The Ch/HA hydrogels after bulk modification promoted better cell adhesion, growth and proliferation than the samples prepared by using Method 2 (surface modification).

Indexed as

chitosancovalently cross-liked chitosangenipinhyaluronic acidL929 mouse fibroblaststissue engineering

Identifiers

PMID37242945
PMCPMC10222357
OpenAlexW4377139483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.