Evidence map›Paper›PMID 37243171›Full record

ArticleViruses2023

Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19.

Anna Gvozdjáková, Jarmila Kucharská, Zuzana Rausová, Guillermo Lopéz-Lluch, Plácido Navas, Patrik Palacka, Barbora Bartolčičová, Zuzana Sumbalová

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anna GvozdjákováPharmacobiochemical Laboratory of 3rd Medical Department, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.
Jarmila KucharskáPharmacobiochemical Laboratory of 3rd Medical Department, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.
Zuzana RausováPharmacobiochemical Laboratory of 3rd Medical Department, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.
Guillermo Lopéz-LluchCentro Andaluz de Biologia del Desarrollo, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-3A and CIBERER, 41013 Seville, Spain.ORCID 0000-0001-9830-8502
Plácido NavasCentro Andaluz de Biologia del Desarrollo, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-3A and CIBERER, 41013 Seville, Spain.ORCID 0000-0002-4115-7966
Patrik Palacka2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.ORCID 0000-0003-4505-0952
Barbora BartolčičováFaculty of Civil Engineering, Slovak Technical University, 811 07 Bratislava, Slovakia.
Zuzana SumbalováPharmacobiochemical Laboratory of 3rd Medical Department, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.ORCID 0000-0001-9454-6255
Comenius University Bratislava · SKInstituto de Salud Carlos III · ESSlovak University of Technology in Bratislava · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitochondrial dysfunction and redox cellular imbalance indicate crucial function in COVID-19 pathogenesis. Since 11 March 2020, a global pandemic, health crisis and economic disruption has been caused by SARS-CoV-2 virus. Vaccination is considered one of the most effective strategies for preventing viral infection. We tested the hypothesis that preventive vaccination affects the reduced bioenergetics of platelet mitochondria and the biosynthesis of endogenous coenzyme Q MATERIAL AND

methods10 vaccinated patients with post-acute COVID-19 (V + PAC19) and 10 unvaccinated patients with post-acute COVID-19 (PAC19) were included in the study. The control group (C) consisted of 16 healthy volunteers. Platelet mitochondrial bioenergy function was determined with HRR method. CoQ

resultsVaccination protected platelet mitochondrial bioenergy function but not endogenous CoQ

conclusionsVaccination against SARS-CoV-2 virus infection prevented the reduction of platelet mitochondrial respiration and energy production. The mechanism of suppression of CoQ

Indexed as

COVID-19HumansMitochondriaOxidation-ReductionSARS-CoV-2Vaccinationantioxidantscoenzyme Q10lipid peroxidationmitochondrial oxidative phosphorylationplateletspost-acute COVID-19SARS-CoV-2 virusvaccination

Identifiers

PMID37243171
PMCPMC10223181
OpenAlexW4367626610

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.