Evidence map›Paper›PMID 37245392›Full record

ArticleCell calcium2023

Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.

Ryan B Williams, Md Nure Alam Afsar, Svetlana Tikunova, Yongjun Kou, Xuan Fang, Radha P Somarathne, Rita F Gyawu, Garrett M Knotts, Taylor A Agee, Sara A Garcia and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Molecular Insights into the MLCK Activation by CaM.Journal of chemical information and modeling · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ryan B WilliamsDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Md Nure Alam AfsarDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Svetlana TikunovaDepartment of Physiology and Cell Biology, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus OH 43210, U.S.A.
Yongjun KouDepartment of Physiology and Cell Biology, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus OH 43210, U.S.A.
Xuan FangDepartment of Cell and Molecular Physiology, Loyola University of Chicago, Maywood Illinois 60153, U.S.A.
Radha P SomarathneDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Rita F GyawuDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Garrett M KnottsDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Taylor A AgeeDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Sara A GarciaDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Luke D LosordoDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A.
Peter M Kekenes-HuskeyDepartment of Cell and Molecular Physiology, Loyola University of Chicago, Maywood Illinois 60153, U.S.A.
Jonathan P DavisDepartment of Physiology and Cell Biology, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus OH 43210, U.S.A. Electronic address: davis.812@osu.edu.
Christopher N JohnsonDepartment of Chemistry, Mississippi State University, Starkville MS 39759, U.S.A; Vanderbilt Center for Arrhythmia Research and Therapeutics, Nashville TN 37232, U.S.A. Electronic address: cn.johnson@chemistry.msstate.edu.
Mississippi State University · USThe Ohio State University · USLoyola University Chicago · US

Funding

Regulation and Dysregulation of Cardiac EC coupling by CalmodulinR01HL138579 · NHLBI · OHIO STATE UNIVERSITY · PI Jonathan Paul Davis, Sandor Gyorke · 2017 to 2026
$6.1M
Calcium modification of voltage gated sodium channelsR35GM142868 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI JOHNSON, CHRISTOPHER N. · 2021 to 2025
$2.0M
Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR01AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2018 to 2022
$1.8M
Probing macrophage cell nucleotide sensing and calcium signaling through computationR35GM148284 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Peter Michael Kekenes-Huskey · 2023 to 2026
$1.5M
NHLBI NIH HHS R01 HL138579NIAID NIH HHS R01 AI139479NIGMS NIH HHS R35 GM142868NIGMS NIH HHS R35 GM148284
6 · The paper itself

Abstract

Calmodulin (CaM) is a ubiquitous, calcium-sensing protein that regulates a multitude of processes throughout the body. In response to changes in [Ca

Indexed as

CalcineurinCalmodulinAnimalsCalciumCalcium SignalingHumansMammalsMutationProtein BindingCalcineurinCalciumCalmodulinCalcineurin (CaN)Calcium signalingHuman disease-associated calmodulin mutationsMechanisms of calmodulinopathy

Identifiers

PMID37245392
PMCPMC10330910
OpenAlexW4378640147

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.