Evidence map›Paper›PMID 37246192›Full record

ArticlePurinergic signalling2024

Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons.

M Diez-Zaera, A Ruiz-Calvo, J I Diaz-Hernandez, A Sebastián-Serrano, P Aivar, B Alvarez-Castelao, J Pintor, M Diaz-Hernandez, M T Miras-Portugal

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M Diez-Zaera *Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
A Ruiz-Calvo *Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
J I Diaz-HernandezDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
A Sebastián-SerranoDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
P AivarDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
B Alvarez-CastelaoDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
J PintorDepartamento de Bioquímica y Biología Molecular, Facultad de Óptica y Optometría, Universidad Complutense de Madrid, 28037, Madrid, Spain.
M Diaz-HernandezDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain. migueldiaz@ucm.es.ORCID 0000-0002-1952-4600
M T Miras-PortugalDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain.
Universidad Complutense de Madrid · ES

Funding

Amphetamine-mediated CREB phosphorylation &gene expressK01DA014057 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI RAJADHYAKSHA, ANJALI M · 2000 to 2004
$591k
Comunidad de Madrid Talento-2019T1/BMD-14057European Commission MSCA-ITN-2017 number 766 124Ministerio de Ciencia e Innovación PID2021-125364OB-I00Ministerio de Ciencia e Innovación RYC2018-024435-I and PID2020-113270RA-I00Spanish Ministry of Economy and Competitiveness RTI2018-095753-B-I00UCM-Santander Central Hispano Bank PR41/17-21014Universidad Complutense de Madrid CT48/19
6 · The paper itself

Abstract

During the establishment of neuronal circuits, axons and dendrites grow and branch to establish specific synaptic connections. This complex process is highly regulated by positive and negative extracellular cues guiding the axons and dendrites. Our group was pioneer in describing that one of these signals are the extracellular purines. We found that extracellular ATP, through its selective ionotropic P2X7 receptor (P2X7R), negatively regulates axonal growth and branching. Here, we evaluate if other purinergic compounds, such as the diadenosine pentaphosphate (Ap

Indexed as

Adenosine TriphosphateDinucleoside PhosphatesReceptors, Purinergic P2DendritesHippocampusNeuronsAdenosine TriphosphateDinucleoside PhosphatesP(1),P(5)-di(adenosine-5'-)pentaphosphateReceptors, Purinergic P2Ap5ADendrite growthP2X1

Identifiers

PMID37246192
PMCPMC10997559
OpenAlexW4378627945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.