Evidence map›Paper›PMID 37246509›Full record

Observational studyInternational psychogeriatrics2023

Malnutrition and neuropsychiatric symptoms in dementia: the Cache County Dementia Progression Study.

Kaitlyn Kauzor, Mikaela Drewel, Hector Gonzalez, Gail B Rattinger, Alexandra G Hammond, Heidi Wengreen, Constantine G Lyketsos, JoAnn T Tschanz

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International psychogeriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kaitlyn KauzorDepartment of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT 84321-2810, USA.
Mikaela DrewelDepartment of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT 84321-2810, USA.
Hector GonzalezDepartment of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT 84321-2810, USA.
Gail B RattingerSchool of Pharmacy and Pharmaceutical Sciences, Binghamton University, P.O. Box 6000. Binghamton, NY 13902-6000, USA.
Alexandra G HammondDepartment of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT 84321-2810, USA.
Heidi WengreenNutrition Dietetics and Food Sciences, Utah State University, 8710 Old Main Hill, Logan, UT 84322-8710, USA.
Constantine G LyketsosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, 5300 Alpha Commons Drive, 4th Floor, Baltimore, MD 21224, USA.
JoAnn T TschanzDepartment of Psychology, Utah State University, 2810 Old Main Hill, Logan, UT 84321-2810, USA.ORCID 0000-0003-1766-2556
Utah State University · USBinghamton University · USJohns Hopkins University · US

Funding

EPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAHR01AG011380 · NIA · JOHNS HOPKINS UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 1994 to 2009
$12.2M
Progression of Dementia: A Population StudyR01AG021136 · NIA · UTAH STATE UNIVERSITY · PI LYKETSOS, CONSTANTINE G, TSCHANZ, JOANN T · 2002 to 2010
$6.0M
THE CACHE COUNTY FAMILY BASED COHORT STUDY ON AGINGR01AG018712 · NIA · UTAH STATE UNIVERSITY · PI MUNGER, RONALD G · 2000 to 2002
$2.0M
NIA NIH HHS R01 AG011380NIA NIH HHS R01 AG018712NIA NIH HHS R01 AG021136
6 · The paper itself

Abstract

objectivesAmong people with dementia, poor nutritional status has been associated with worse cognitive and functional decline, but few studies have examined its association with neuropsychiatric symptoms (NPS). We examined this topic in a population-based sample of persons with dementia.

designLongitudinal, observational cohort study.

settingCommunity.

participantsTwo hundred ninety-two persons with dementia (71.9% Alzheimer's disease, 56.2% women) were followed up to 6 years. MEASUREMENTS: We used a modified Mini-Nutritional Assessment (mMNA) and the Neuropsychiatric Inventory (NPI) to evaluate nutritional status and NPS, respectively. Individual linear mixed effects models examined the associations between time-varying mMNA total score or clinical categories (malnourishment, risk for malnourishment, or well-nourished) and NPI total score (excluding appetite domain) or NPI individual domain or cluster (e.g. psychosis) scores. Covariates tested were dementia onset age, type, and duration, medical comorbidities, sex, apolipoprotein E (APOE) genotype, and education.

resultsCompared to the well-nourished, those at risk for malnourishment and those malnourished had higher total NPI scores [

conclusionsWorse nutritional status is associated with more severe NPS. Dietary or behavioral interventions to prevent malnutrition may be beneficial for persons with dementia.

Indexed as

Alzheimer DiseaseDementiaMalnutritionCohort StudiesFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsAlzheimer’s disease (AD)behavioral and psychological symptoms of dementia (BPSD)dementianeuropsychiatric symptomsnutrition

Identifiers

PMID37246509
PMCPMC10592578
OpenAlexW4378619887

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.