Evidence map›Paper›PMID 37246709›Full record

ArticleNucleic acids research2023

sfkit: a web-based toolkit for secure and federated genomic analysis.

Simon Mendelsohn, David Froelicher, Denis Loginov, David Bernick, Bonnie Berger, Hyunghoon Cho

Abstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Privacy-Enhancing Technologies in Biomedical Data Science.Annual review of biomedical data science · 2024
    Review
  6. Review
  7. Secure Discovery of Genetic Relatives across Large-Scale and Distributed Genomic Datasets.Research in computational molecular biology : ... Annual International Conference, RECOMB ... : proceedings. RECOMB (Conference : 2005- )
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simon MendelsohnBroad Institute of MIT and Harvard, Cambridge, MA, USA.
David FroelicherBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Denis LoginovBroad Institute of MIT and Harvard, Cambridge, MA, USA.
David BernickBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Bonnie BergerBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2724-7228
Hyunghoon ChoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2713-0150

Funding

Genetic & Social Determinants of Health: Center for Admixture Science and TechnologyRM1HG011558 · NHGRI · YALE UNIVERSITY · PI FRAZER, KELLY A, GYMREK, MELISSA · 2021 to 2025
$11.2M
Privacy-preserving genomic medicine at scaleR01HG010959 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE · 2020 to 2023
$2.6M
Computational Methods for Enhancing Privacy in Biomedical Data SharingDP5OD029574 · OD · YALE UNIVERSITY · PI CHO, HYUNGHOON · 2020 to 2024
$2.0M
Manifold representations and active learning for 21 st century biologyR35GM141861 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE · 2021 to 2025
$1.9M
NHGRI NIH HHS R01 HG010959NHGRI NIH HHS RM1 HG011558NIGMS NIH HHS R35 GM141861NIH HHS DP5 OD029574NIH HHS R01 HG010959
6 · The paper itself

Abstract

Advances in genomics are increasingly depending upon the ability to analyze large and diverse genomic data collections, which are often difficult to amass due to privacy concerns. Recent works have shown that it is possible to jointly analyze datasets held by multiple parties, while provably preserving the privacy of each party's dataset using cryptographic techniques. However, these tools have been challenging to use in practice due to the complexities of the required setup and coordination among the parties. We present sfkit, a secure and federated toolkit for collaborative genomic studies, to allow groups of collaborators to easily perform joint analyses of their datasets without compromising privacy. sfkit consists of a web server and a command-line interface, which together support a range of use cases including both auto-configured and user-supplied computational environments. sfkit provides collaborative workflows for the essential tasks of genome-wide association study (GWAS) and principal component analysis (PCA). We envision sfkit becoming a one-stop server for secure collaborative tools for a broad range of genomic analyses. sfkit is open-source and available at: https://sfkit.org.

Indexed as

Genome-Wide Association StudyGenomicsSoftwareInternetPrivacyWorkflow

Identifiers

PMID37246709
PMCPMC10320181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.