← Metformin × pregnancy & neonatal

SynthesisIrish journal of medical science2024

Prophylactic administration of metformin reduces gestational diabetes mellitus incidence in the high-risk populations: a meta-analysis : Metformin for gestational diabetes prevention.

Hui Yu et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 3,911 people · 2024

Randomised comparison

Lowered pregnancy & neonatal

−69%−77% to −59%

Bigger than 9 in 10 on the map

As reported

RR 0.31, 95% CI 0.23–0.41

Randomised comparison

Lowered pregnancy & neonatal

−58%−74% to −32%

Bigger than 9 in 10 on the map

As reported

RR 0.42, 95% CI 0.26–0.68

Randomised comparison

Lowered pregnancy & neonatal

−41%−58% to −17%

Bigger than 8 in 10 on the map

As reported

RR 0.59, 95% CI 0.42–0.83

Three numbers in the abstract

the abstract, start to end

… patients' types: (1) in Asians (RR = 0.31, 95% CI: 0.23-0.41), (2) in PCOS patients (RR = 0.42, 95% CI: 0.26-0.68), and (3) in patients receiving high dose of metformin (mean dose > 1000 mg) (RR = 0.59, 95% CI: 0.42-0.83).

← favours treatmentfavours comparator →
could be chance
Pregnancy & neonatal
RR 0.310.23–0.41
Pregnancy & neonatal
RR 0.420.26–0.68
Pregnancy & neonatal
RR 0.590.42–0.83
MetforminPregnancy & neonatal

Metformin × pregnancy & neonatalhelps?mixed

unlikelylikely
0.00not counted
← favours treatmentfavours comparator →
more certainless certain
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5 papers cite it

2024
2025
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Full record →Abstract, authors, funding and every citing paper · PMID 37248332