Evidence map›Paper›PMID 37250804›Full record

ArticleiScience2023

Genetically proxied impaired GIPR signaling and risk of 6 cancers.

Miranda Rogers, Dipender Gill, Emma Ahlqvist, Tim Robinson, Daniela Mariosa, Mattias Johansson, Ricardo Cortez Cardoso Penha, Laure Dossus, Marc J Gunter, Victor Moreno and 3 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Miranda RogersMRC Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, W2 1PG London, UK.
Emma AhlqvistDepartment of Clinical Sciences, Lund University, Lund, 22362 Malmö, Sweden.
Tim RobinsonMRC Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
Daniela MariosaGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 69007 Lyon, France.
Mattias JohanssonGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 69007 Lyon, France.
Ricardo Cortez Cardoso PenhaGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 69007 Lyon, France.
Laure DossusNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), 69007 Lyon, France.
Marc J GunterNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), 69007 Lyon, France.
Victor MorenoBiomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
Richard M MartinMRC Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
James YarmolinskyMRC Integrative Epidemiology Unit, University of Bristol, BS8 2BN Bristol, UK.
Centre International de Recherche sur le Cancer · FRUniversity of Bristol · GBInstitut Català d'Oncologia · ESLund University · SENovo Nordisk (Denmark) · DKUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
Cancer Research UK 28534Cancer Research UK 29019Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00032/1NCI NIH HHS R01 CA128978NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537World Health Organization 001
6 · The paper itself

Abstract

Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in

Indexed as

CancerGeneticsHealth sciences

Identifiers

PMID37250804
PMCPMC10209536
OpenAlexW4378745592

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.