ArticleNeurobiology of stress2023
The stress of losing sleep: Sex-specific neurobiological outcomes.
Article in Neurobiology of stress, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Suicide and Sleep Disorders: The Role of Insomnia, Nightmares, and Circadian Disruption.Cureus · 2026Review
- Not All Sleep Loss Is Equal: A Comprehensive Evaluation of Rodent Models, Their Neurobiological Validity, and Translational Relevance to Neurological Disease.Biomedicines · 2026Review
- Association between nocturnal ozone enhancement and daily cardiovascular mortality: A multi-city study in China.Eco-Environment & Health · 2026Article
- Electroacupuncture improves neurocognitive impairment induced by chronic sleep deprivation: an experimental study based on hippocampal neurogenesis and synaptic plasticity.Frontiers in human neuroscience · 2026Article
- Bidirectional Predictors Between Neurobehavioural Measures During Total Sleep Deprivation and Baseline and Recovery Sleep Measures.Journal of sleep research · 2025Article
- A Sleeping Opportunity Does Not Restore Hippocampal Alterations Induced by 10 Days of Sleep Restriction in Rats.Neurochemical research · 2025Article
- Article
- Sex Differences in the Association between Sleep Quality and Excess Weight: Exploring Lifestyle and Health-Related Mediators.Sleep science (Sao Paulo, Brazil) · 2025Article
- Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders.Biomedicines · 2025Review
- Bidirectional predictors between baseline and recovery sleep measures and cardiovascular measures during sleep deprivation and psychological stress.Physiological reports · 2025Article
- Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis.World journal of orthopedics · 2025Article
- Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats.Behavioral and brain functions : BBF · 2025Article
- Sleep deprivation stimulates adaptive thermogenesis by activating AMPK pathway in mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- A deep learning software tool for automated sleep staging in rats via single channel EEG.NPP - digital psychiatry and neuroscience · 2025Article
- Sleep deprivation affects memory function, depression and anxiety-like behaviours in rats and mice: a systematic review and meta-analysis.Brain communications · 2025Review
- Loneliness and nervousness mediated the longitudinal association between sleep disorders and cyberbullying victimization in school-aged adolescents.Frontiers in psychiatry · 2025Article
- Integrative approaches to studying sleep, stress, and related disorders.Neurobiology of stress · 2025Article
- Cholecystokinin-expressing interneurons mediated inhibitory transmission and plasticity in basolateral amygdala modulate stress-induced anxiety-like behaviors in mice.Neurobiology of stress · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is a vital and evolutionarily conserved process, critical to daily functioning and homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental physiological outcomes. Despite sleep disturbances affecting everyone, women and female rodents are often excluded or underrepresented in clinical and pre-clinical studies. Advancing our understanding of the role of biological sex in the responses to sleep loss stands to greatly improve our ability to understand and treat health consequences of insufficient sleep. As such, this review discusses sex differences in response to sleep deprivation, with a focus on the sympathetic nervous system stress response and activation of the hypothalamic-pituitary-adrenal (HPA) axis. We review sex differences in several stress-related consequences of sleep loss, including inflammation, learning and memory deficits, and mood related changes. Focusing on women's health, we discuss the effects of sleep deprivation during the peripartum period. In closing, we present neurobiological mechanisms, including the contribution of sex hormones, orexins, circadian timing systems, and astrocytic neuromodulation, that may underlie potential sex differences in sleep deprivation responses.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.