ArticleeLife2023
Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.
Open access · goldAbstract read
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
15.1field-weighted citation impact, top 1% of its field
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Who cites it
55 citing papers in PubMed, 63 citations in OpenAlex.
- Isolation of Bacteria and Fungi from Human Pancreatic Tumors and Duodenum.Gut microbes · 2026Article
- Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).Molecular medicine reports · 2026Review
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- A Full Spectrum Fibroblast Profiling Panel Reveals Phenotypic and Metabolic Heterogeneity of Cancer-Associated Fibroblasts at the Single-Cell Level.bioRxiv : the preprint server for biology · 2026Article
- Article
- Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer.Cancer immunology research · 2026Article
- Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming.Cancer research · 2026Article
- Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia.The Biochemical journal · 2026Review
- Tissue-specific tolerance mechanisms and lymph node co-drainage shape T cell immunity in the upper digestive system and pancreatic cancer progression.Cell reports · 2026Article
- Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment.bioRxiv : the preprint server for biology · 2026Article
- Review
- Article
- The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer.Molecular cell · 2026Article
- Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment.Nature reviews. Cancer · 2026Review
- A multi-omic approach reveals iron availability influences cell fate fidelity.npj metabolic health and disease · 2026Article
- Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer.Cancer research · 2026Article
- Review
- A step-by-step guide to performing cancer metabolism research using custom-made media.Life science alliance · 2026Article
- Tumor-immune metabolic tug-of-war: from immune escape to targeting metabolic rewiring in cancer therapy.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Juan J Apiz Saab *Ben May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0002-4799-9291
Lindsey N Dzierozynski *Ben May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0001-5775-5429
Patrick B JonkerBen May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0002-5074-3035
Roya AminiTabriziMetabolomics Platform, Comprehensive Cancer Center, University of Chicago, Chicago, United States.
Hardik ShahMetabolomics Platform, Comprehensive Cancer Center, University of Chicago, Chicago, United States.
Rosa Elena MenjivarCellular and Molecular Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States.
Andrew J ScottDepartment of Radiation Oncology, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-0835-4888
Zeribe C NwosuDepartment of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.
Zhou ZhuBen May Department for Cancer Research, University of Chicago, Chicago, United States.
Riona N ChenBen May Department for Cancer Research, University of Chicago, Chicago, United States.
Moses OhBen May Department for Cancer Research, University of Chicago, Chicago, United States.
Colin SheehanBen May Department for Cancer Research, University of Chicago, Chicago, United States.
Daniel R WahlDepartment of Radiation Oncology, University of Michigan, Ann Arbor, United States.
Marina Pasca di MaglianoCellular and Molecular Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.
Kay F MacleodBen May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0002-8995-4155
Christopher R WeberDepartment of Pathology, University of Chicago, Chicago, United States.
Alexander MuirBen May Department for Cancer Research, University of Chicago, Chicago, United States.ORCID 0000-0003-3811-3054
University of Chicago · USUniversity of Michigan · USJohns Hopkins University · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2MVIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1MThe Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6MPUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MMulti-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MTRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MFunctions of BNIP3 in lipid metabolism in the liver and in hepatocellular carcinomaR01CA200310 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD · 2016 to 2026
$3.6MNCATS NIH HHS UL1 TR002389NCI NIH HHS F31 CA257533NCI NIH HHS F32 CA260735NCI NIH HHS K08 CA234416NCI NIH HHS K99 CA267176NCI NIH HHS P30 CA014599NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA200310NCI NIH HHS R37 CA237421NCI NIH HHS R37 CA258346NCI NIH HHS T32 CA009594NICHD NIH HHS T32 HD007505NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572NIDDK NIH HHS U2C DK110768NIGMS NIH HHS R25 GM086262NIGMS NIH HHS R25 GM143298NIGMS NIH HHS T32 GM007315NINDS NIH HHS R01 NS129123
Abstract
Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical to understand the metabolism underpinning cancer cell biology. Previously, we performed quantitative metabolomics of the interstitial fluid (the local perfusate) of murine pancreatic ductal adenocarcinoma (PDAC) tumors to comprehensively characterize nutrient availability in the microenvironment of these tumors. Here, we develop
Indexed as
Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAmino AcidsAnimalsArginineCell Line, TumorMiceTumor MicroenvironmentAmino AcidsArginineamino acid homeostasisargininebiochemistrycancer biologychemical biologyhumanmetabolismmousenutrient stresstumor microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.